All Pharmaceutical Microbiology articles – Page 12
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NewsGenotype-specific response to 144-week entecavir therapy for HBeAg-positive chronic hepatitis B
HBV genotype B demonstrates superior histological responses to ETV therapy compared with genotype C, supporting the clinical value of HBV genotyping for personalized CHB management. These findings highlight the importance of considering viral genotype when evaluating treatment outcomes.
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NewsEthris and German Center for Infection Research (DZIF) announce strategic collaboration to develop mRNA-based vaccines
Ethris GmbH, a clinical-stage biotechnology company pioneering next-generation RNA therapeutics and vaccines, and the German Center for Infection Research (DZIF), have announced a strategic research collaboration to develop mRNA-based vaccines for the prevention and treatment of infectious diseases.
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NewsResearchers on the cusp of a vaccine for a global health threat
Researchers are on the cusp of a new vaccine to prevent chikungunya, a global health threat which attacks human joint tissue. The team tested whether they could engineer E. coli to assemble biopolymer particles which displayed chikungunya antigens and performed as a vaccine.
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NewsDiscovery of SARS-CoV-2 PLpro inhibitors and RIPK1 inhibitors with synergistic antiviral efficacy in a mouse COVID-19 model
A new article publication discusses the discovery of SARS-CoV-2 PLpro inhibitors and RIPK1 inhibitors with synergistic antiviral efficacy in a mouse COVID-19 model.
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New vaccine platform promotes rare protective B cells
Based on a virus-like particle built with a DNA scaffold, the approach could generate broadly neutralizing antibody responses against HIV or influenza.
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NewsGreen chemistry: Friendly bacteria can unlock hidden metabolic pathways in plant cell cultures
Co-culturing plant cells with harmless bacteria can expand the diversity of obtainable plant-derived compounds for pharmaceuticals, cosmetics, and agrochemicals, a new study shows.
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NewsScientists demonstrate first-ever single-shot HIV vaccine neutralization success
Scientists have developed an HIV vaccine candidate that achieves something never before observed in the field: inducing neutralizing antibodies against HIV after a single immunization in nonhuman primates.
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NewsLaunch of clinical trial of investigative nasal spray medicine to prevent illnesses from respiratory viruses
A new clinical trial will test a new experimental intranasal spray designed to boost immune defenses and reduce illness from respiratory viruses.
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NewsResearchers enable microorganisms to build molecules with light
Researchers are continually looking for new ways to hack the cellular machinery of microbes to make useful products. A new study shows they can expand the biosynthetic capabilities of these microbes by using light to help access new types of chemical transformations.
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NewsSynthetic compound has the potential to treat malaria and prevent its transmission
Tests on cell cultures and rodents have shown that the new molecule acts on all three stages of the disease cycle, eliminating the parasite from human blood and liver and preventing transmission to mosquitoes.
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NewsNatural sunscreen compounds show potential to support skin health and blood pressure
Researchers have discovered that natural ‘sunscreen’ compounds found in algae and cyanobacteria may also support skin and heart health.
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NewsDissolved bubble microneedles enable more efficient therapy of acne vulgaris
Researchers report a new microneedle-based strategy for acne therapy in a new study. The team developed dissolved bubble microneedle patches that can simultaneously deliver hydrophilic and hydrophobic drugs directly into acne-affected skin.
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NewsMetformin shown to prevent Long COVID across risk groups in multiple randomized trials
Multiple randomized clinical trials and electronic health record studies now show that metformin, a widely used and well-established medication, significantly reduces the risk of developing Long COVID when taken during or shortly after acute infection with SARS-CoV-2.
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NewsAntibiotic therapy: is shorter just as effective?
Shorter-duration antibiotic therapy shows comparable success to longer-duration treatment in children with community-acquired pneumonia. However, a general conclusion about a shortened treatment duration is not possible, Tthe authors of a new study say.
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NewsStudy identifies blood protein albumin as key defense against deadly fungal infection ‘mucormycosis’
A new study has identified albumin as a powerful and previously unrecognized defense against a rare but often fatal fungal infection. Patients with mucormycosis had markedly lower levels of albumin compared with patients suffering from other fungal infections.
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News‘Trojan horse’ may deliver toxic dose of copper to bacterial colonies, including drug-resistant MRSA infections
A research team is developing a drug that works in combination with copper to kill bacteria, including those that cause MRSA, a type of staph infection that is resistant to usual treatments.
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NewsScientists synthesize medicarpin in baker’s yeast
Scientists have developed a way to synthesize medicarpin in yeast. Like palitaxel in the 1990s, this tumor-attacking sustance has only limited natural quantitites and is considered difficult to synthesize.
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NewsSniffing out the cause of keratoderma-associated foot odor
The distinct foot odor that comes with the skin disorder Nagashima-type palmoplantar keratosis (NPPK) is caused by the overgrowth of a specific bacterial strain. Topical application of benzoyl peroxide restores balance in the bacterial skin flora, reducing the odor.
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NewsMajor clinical trial provides definitive evidence of impacts of steroid treatment on severe brain infection
A major UK clinical trial has shown that adding the corticosteroid dexamethasone to standard antiviral treatment for encephalitis, caused by herpes simplex virus (HSV) does not improve long-term outcomes overall, although early use may lead to better recovery.
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NewsLithium study yields insights in the fight against HIV
Lithium, a widely used treatment for bipolar disorder and other mood disorders, has shown early promise in suppressing HIV. A new study found lithium can prevent infected cells from reactivating, and that it does so through an unexpected biological mechanism.