All Pharmaceutical Microbiology articles – Page 14
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NewsLargest-ever antibiotic discovery effort uses AI to uncover potential cures in microbial dark matter
Researchers used machine learning to search for antibiotics in a vast dataset containing the recorded genomes of tens of thousands of bacteria and other primitive organisms, yielding nearly one million potential antibiotic compounds.
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NewsBone loss drugs can help azoles fight fungal infections
A new study suggests that adding common bone loss drugs to azoles can improve efficacy. In lab tests, combinations of these drugs worked against dermatophyte species and prevented resistance.
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NewsOral nucleoside antiviral is progressing toward future pandemic preparedness
Oral obeldesivir has been shown to reduce disease severity in mice infected with one of several different coronaviruses, including SARS-CoV-2 (which causes COVID-19), SARS-CoV and MERS-CoV.
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NewsNovel triple antibiotic combination offers breakthrough in combatting antibiotic resistance
A new study unveils a promising triple combination of antibiotics that significantly expands our arsenal against drug-resistant bacteria.
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NewsCaffeine-degrading microbes could tackle coffee pollution - and produce valuable pharmaceutical compounds
Caffeine-degrading microbes could offer vital bioremediation services as well as upcycling coffee waste into valuable pharmaceutical compounds, a new review suggests.
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NewsThe world’s most powerful anti-fungal chemistries cause fungal pathogens to self-destruct
Scientists have discovered that the most widely-used class of antifungals in the world cause pathogens to self-destruct. The research could help improve ways to protect food security and human lives.
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News'Failed drug' could offer new approach to Epstein-Barr virus and resulting diseases
Researchers have found that the Epstein-Barr virus triggers infected cells to ramp up the production of an enzyme known as IDO1, a discovery that offers a promising starting point for putting the brakes on EBV.
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NewsBiotech companies leverage novel tools to develop drugs for RSV
Reporter structures that can be introduced into cells for use in drug screening assays emit fluorescent or bioluminescent light at different intensities when RSV genes are inhibited by the potential antiviral agents being tested.
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NewsMitochondrial phosphate carrier plays an important role in virulence of Candida albicans
Scientists have found that the lack of MIR1 gene, which encodes mitochondrial phosphate carrier, can lead to severe virulence defects in Candida albicans.
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News New small molecule found to suppress the evolution of antibiotic resistance in bacteria
Researchers have developed a new small molecule that can suppress the evolution of antibiotic resistance in bacteria and make resistant bacteria more susceptible to antibiotics.
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NewsDrug-like inhibitor shows promise in preventing flu
Scientists have developed a potential drug-like molecule that blocks the first stage of type A influenza infection.
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NewsMatcha mouthwash inhibits bacteria that causes periodontitis
Matcha, a finely ground green tea powder, may help inhibit the growth of Porphyromonas gingivalis, one of the chief bacterial culprits behind periodontitis.
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NewsResearchers may have come up with second chance for antibiotic agent
A new study focuses on the protein peptide deformylase (PDF), which is involved in protein maturation processes in bacterial cells. While the original drug candidate had to be discarded, modification of the molecule could offer a second chance.
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NewsStudy paves the way for an active agent against hepatitis E
Tests in cell culture with human liver cells showed that the compound K11777 prevents infection with hepatitis E viruses.
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NewsBiophysicist F. William Studier awarded Merkin prize in biomedical technology
F. William Studier, a senior biophysicist emeritus at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory, has won the 2024 Richard N. Merkin Prize in Biomedical Technology for his development in the 1980s of an efficient, scalable method of producing RNA and proteins in the laboratory. Source: ...
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NewsStudy reveals how dopamine inhibits the expression of hepatitis B virus surface and e antigens
A new study finds that dopamine inhibits the expression of hepatitis B virus surface and e antigens - HBsAg and HBeAg - by activating the JAK/STAT pathway and upregulating ISG15 expression.
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NewsYour Pseudomonas aeruginosa biofilm may vary - depending on where it turns up
The bacterium Pseudomonas aeruginosa adapts its biofilm form depending on the infectious site where it is found, potentially affecting antibiotic sensitivity, according to new research being presented at the Letters in Applied Microbiology ECS Research Symposium today.
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NewsEnzyme that reproduces Meinwald reaction offers hope as bionanomachine for green chemistry
Researchers have for the first time precisely characterised the enzyme styrene oxide isomerase, which can be used to produce valuable chemicals and drug precursors in an environmentally friendly manner.
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NewsAncient remedy is reworked to create medicinal cocktail targeting drug-resistant bacteria
A mediaeval remedy used to cure a “lump in the eye” - interpreted as a sign of bacterial infection - more than 1,000 years ago has been reworked into a pharmaceutical product with potent antibiofilm activity, delegates will hear at the Letters in Applied Microbiology ECS Research Symposium.
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NewsKeto diet boosts lifesaving antifungal drug in mice
In animal tests, researchers have found that taking fluconazole in combination with a low-carb, high-fat keto diet worked significantly better at killing the fungus behind fungal meningitis than taking the medication alone.