All Pharmaceutical Microbiology articles – Page 19
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NewsBiotech companies leverage novel tools to develop drugs for RSV
Reporter structures that can be introduced into cells for use in drug screening assays emit fluorescent or bioluminescent light at different intensities when RSV genes are inhibited by the potential antiviral agents being tested.
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NewsMitochondrial phosphate carrier plays an important role in virulence of Candida albicans
Scientists have found that the lack of MIR1 gene, which encodes mitochondrial phosphate carrier, can lead to severe virulence defects in Candida albicans.
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News New small molecule found to suppress the evolution of antibiotic resistance in bacteria
Researchers have developed a new small molecule that can suppress the evolution of antibiotic resistance in bacteria and make resistant bacteria more susceptible to antibiotics.
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![Low-Res_Compound 7 with influenza H1 hemagglutinin_Credit Seiya Kitamura[1]](https://d3rmrttq0bsnxi.cloudfront.net/Pictures/100x67/4/1/4/7414_lowres_compound7withinfluenzah1hemagglutinin_creditseiyakitamura1_295508_crop.jpg)
NewsDrug-like inhibitor shows promise in preventing flu
Scientists have developed a potential drug-like molecule that blocks the first stage of type A influenza infection.
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NewsMatcha mouthwash inhibits bacteria that causes periodontitis
Matcha, a finely ground green tea powder, may help inhibit the growth of Porphyromonas gingivalis, one of the chief bacterial culprits behind periodontitis.
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NewsResearchers may have come up with second chance for antibiotic agent
A new study focuses on the protein peptide deformylase (PDF), which is involved in protein maturation processes in bacterial cells. While the original drug candidate had to be discarded, modification of the molecule could offer a second chance.
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NewsStudy paves the way for an active agent against hepatitis E
Tests in cell culture with human liver cells showed that the compound K11777 prevents infection with hepatitis E viruses.
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NewsBiophysicist F. William Studier awarded Merkin prize in biomedical technology
F. William Studier, a senior biophysicist emeritus at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory, has won the 2024 Richard N. Merkin Prize in Biomedical Technology for his development in the 1980s of an efficient, scalable method of producing RNA and proteins in the laboratory. Source: ...
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NewsStudy reveals how dopamine inhibits the expression of hepatitis B virus surface and e antigens
A new study finds that dopamine inhibits the expression of hepatitis B virus surface and e antigens - HBsAg and HBeAg - by activating the JAK/STAT pathway and upregulating ISG15 expression.
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NewsYour Pseudomonas aeruginosa biofilm may vary - depending on where it turns up
The bacterium Pseudomonas aeruginosa adapts its biofilm form depending on the infectious site where it is found, potentially affecting antibiotic sensitivity, according to new research being presented at the Letters in Applied Microbiology ECS Research Symposium today.
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NewsEnzyme that reproduces Meinwald reaction offers hope as bionanomachine for green chemistry
Researchers have for the first time precisely characterised the enzyme styrene oxide isomerase, which can be used to produce valuable chemicals and drug precursors in an environmentally friendly manner.
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NewsAncient remedy is reworked to create medicinal cocktail targeting drug-resistant bacteria
A mediaeval remedy used to cure a “lump in the eye” - interpreted as a sign of bacterial infection - more than 1,000 years ago has been reworked into a pharmaceutical product with potent antibiofilm activity, delegates will hear at the Letters in Applied Microbiology ECS Research Symposium.
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NewsKeto diet boosts lifesaving antifungal drug in mice
In animal tests, researchers have found that taking fluconazole in combination with a low-carb, high-fat keto diet worked significantly better at killing the fungus behind fungal meningitis than taking the medication alone.
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NewsUT Health San Antonio to lead $11m study of a first-ever oral chlamydia vaccine
The study of a novel oral vaccine that could protect against chlamydia infection has been awarded approximately $11 million in National Institutes of Health funding over five years through a cooperative agreements research project grant.
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NewsResearchers may have found an Achilles heel for Hepatitis B
Researchers have revealed never-before-seen mechanisms that may lead to new therapeutic approaches for HBV.
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NewsScientists probe spermidine production to combat emerging drug resistance in Salmonella
Scientists have pinpointed how Salmonella Typhimurium uses a key molecule called spermidine to shield itself from the onslaught of the host’s defence machinery - and an existing FDA-approved drug can reduce spermidine production.
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NewsDecoding the complex genetic network of antimicrobial resistance in Campylobacter jejuni
A study focused on tetracycline resistance genes tetO and tetM - using phylogenetic tree analysis, it provided valuable insights into the genetic landscape and variants associated with C. jejuni.
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NewsAn adjuvant made in yeast could lower vaccine cost and boost availability
Scientists have wielded the power of synthetic biology to produce the active ingredient of soap bark, a molecule called QS-21, in yeast - a more environmentally friendly way to produce a key ingredient of vaccines.
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NewsTenofovir alafenamide treatment achieves positive results in Chinese chronic hepatitis B patients
A five-year treatment regime with tenofovir alafenamide achieves high rates of viral suppression, alanine aminotransferase normalization, and favorable bone and renal safety in Chinese chronic hepatitis B patients.
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NewsStudy finds diabetes drug reduces COVID-19 viral load and viral rebound
Researchers have found that metformin, a drug commonly used to treat diabetes, can decrease the amount of COVID-19 virus in the body and lower the chances of the virus coming back strongly after initial treatment.