All Pharmaceutical Microbiology articles – Page 16
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NewsBirmingham Drug Discovery Hub creates an investment-ready ‘drug library’
A novel approach to drug discovery is enabling University of Birmingham researchers to overcome the ‘valley of death’, where projects fail due to the funding gap between original research and commercial investment.
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NewsNew class of antimicrobials discovered in soil bacteria
Scientists have mined Streptomyces for antibiotics for nearly a century, but the newly identified umbrella toxin escaped notice.
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NewsNanoparticle enhances antibacterial sonodynamic therapy for eradication of Pseudomonas aeruginosa biofilm
A novel ultrasound-launched targeted nanoparticle was developed to universally destroy biofilm, target bacteria, deliver antibiotics, and efficiently kill bacteria via ultrasonic cavitation and antibacterial sonodynamic therapy.
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NewsMechanism of action of the hepatitis B and D virus cell entry inhibitor bulevirtide deciphered
An international research team has succeeded in deciphering the molecular structure of bulevirtide in complex with the HBV/HDV receptor NTCP at the molecular level.
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NewsCollaboration garners new support to tackle high-value tuberculosis targets
A groundbreaking collaboration will combat global health challenges in tuberculosis through innovative technology.
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NewsMembrane-piercing drugs bring multidrug-resistant pathogens to their knees
A research team has introduced a method for the development of novel antibiotics to fight resistant pathogens. The drugs are based on protein building blocks with fluorous lipid chains.
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NewsA combination of approved drugs enhances the delivery of anti-bacterial medications to treat tuberculosis
Scientists repurposed approved drugs that they originally tested to normalize blood vessels surrounding tumors to improve drug delivery to cancer cells.
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NewsScientists develop an innovative compound effective against malaria and leishmaniasis
Initially designed for malaria, this drug shows high efficacy against leishmaniasis, representing a unique and promising breakthrough for the treatment of both infections.
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NewsNew enzymatic cocktail can kill tuberculosis-causing mycobacteria
A new study shows that an enzymatic cocktail can kill a variety of mycobacterial species of bacteria, including those that cause tuberculosis.
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NewsResearchers a step closer to a cure for HIV
A new study demonstrates that a patented therapeutic candidate, an HIV-virus-like-particle (HLP), is 100 times more effective than other candidate HIV cure therapeutics for people living with chronic HIV on combined antiretroviral therapy (cART).
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NewsMaleimide derivative shows promise for treating clinical candidiasis
A new study demonstrates the efficacy of a novel maleimide analogue as a novel antifungal compound, highlighting its potential as a promising option for the treatment of clinical candidiasis.
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NewsBreakthrough antibiotic shows promise against obstinate mycobacterial infections
Researchers assemble a new antibiotic candidate, COE-PNH2, offering a more effective therapeutic option against hard-to-treat mycobacterial lung diseases.
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NewsCancer therapies show promise in combating tuberculosis
A study has identified a combination of medications that may improve blood flow within granulomas, tight clusters of white blood cells formed by the body’s immune system in response to tuberculosis infection, benefiting drug delivery.
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OpinionAntimicrobial chemotherapy - which direction now?
The answer to antimicrobial resistance might not be the continual discovery of new antibiotics - but judicious use of the antibiotics and insights into antibiotic producing organisms we have already discovered.
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NewsResearch uncovers a new path to drug diversity
By exploring protein evolution, scientists have found new “fusion sites” that enable faster and more targeted drug development.
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NewsResearchers invent artificial intelligence model to design new superbug-fighting antibiotics
Researchers have invented a new generative artificial intelligence model which can design billions of new antibiotic molecules that are inexpensive and easy to build in the laboratory.
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NewsTeardrops target multiple COVID variants through the twist in the spike protein
Particles that gum up the keys that the virus uses to enter cells could one day be an effective COVID treatment whenever vaccines and other treatments fall short.
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NewsDrug candidate may ‘unmask’ latent HIV-infected cells, mark them for destruction
Scientists have identified drug candidates that show promise to reverse the ability of HIV to escape detection by the immune system.
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NewsDaff-derived Alzheimer’s drug fermented with help from AI and bacteria moves closer to reality
An innovative approach uses artificial intelligence and biosensors to pave the way for faster drug development.
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NewsLongitudinal gut fungal alterations and potential fungal biomarkers for the progression of primary liver disease
Scientists have found that during liver disease progression, the abundance of Chytridiomycota increased initially, but was later replaced by Ascomycota in HCC.