All Disease Treatment & Prevention articles – Page 8
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NewsStudy identifies serious infection risks linked to targeted cancer therapies
A major real-world study has found serious blood-related side effects associated with antibody-drug conjugates, an increasingly important class of targeted cancer therapies. Some ADCs were associated with substantial rates of severe neutropenia – dangerously low levels of infection-fighting white blood cells – and related complications.
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NewsNew study identifies key warning signs for infection after ankle fracture surgery in older patients
A new study of which patients are most at risk of a fracture-related infection post ankle surgery finds that low protein levels in the blood is the single strongest patient-related risk factor, making infection nearly 18 times more likely. Chronic alcohol abuse and failure to follow post-operative instructions each raise the risk more than fivefold.
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NewsEngineered gut bacteria therapy emerges as scalable potential alternative to fecal microbiota transplants following clinical trial
Researchers have developed a new manufacturing platform for producing targeted mixtures of beneficial gut bacteria, an approach that could help expand access to microbiome-based therapies for patients with recurrent Clostridioides difficile (C. difficile) infection.
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NewsReal-time brain monitor detects infections earlier
A research team has created a new monitoring system to save lives and significantly reduce health-care costs in brain-injury cases through the early detection of infections in intensive care units. NeuroSense connects to drainage lines to detect biomarkers of infection.
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NewsWhat is the link between HIV and chronic pain?
A mouse study reveals a mechanism linking HIV to chronic pain. Targeting each of the molecular players in this mechanism alleviates pain and may hold treatment promise for HIV-associated pain, though more work is needed.
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NewsNew fluorescent nanosensor enables first-of-its-kind detection of key gut health biomarker
Researchers have developed a novel fluorescent nanosensor capable of rapidly detecting indole-3-propionic acid (IPA), an emerging biomarker linked to gut health and disease. The sensor produces a rapid optical readout within minutes, offering a significantly faster and more accessible alternative to conventional analytical techniques.
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NewsPost-discharge antibiotics may offer limited benefit after pediatric appendicitis
Acute appendicitis is one of the most common surgical emergencies among children, and complicated acute appendicitis (CAA), including perforated or gangrenous disease, carries a higher risk of infection and longer hospitalization. While intravenous antibiotics during hospitalization are standard practice, the role of oral home antibiotics (OHA) after discharge remains controversial. ...
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NewsPrecigen presents new long-term durability data for PAPZIMEOS, recently granted seven-year market exclusivity
Precigen, Inc. has announced updated long-term follow-up data from the pivotal study of PAPZIMEOS™ (zopapogene imadenovec-drba) for the treatment of adults with recurrent respiratory papillomatosis (RRP).
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NewsScientists validate a link between autoimmunity in a subset of people with long COVID
A research team has demonstrated that autoimmunity, where the body’s immune system attacks its own tissues, is responsible for the often-debilitating and confounding symptoms of long COVID in a subset of people.
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NewsNew model shows how gut microbes help shape how many calories you absorb from food
A new mathematical model follows food through the digestive tract, estimating what the body absorbs directly, what reaches the colon and how gut microbes help process the remaining material into products that are either absorbed or excreted.
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NewsResearchers may now understand why chikungunya virus infections turn chronic
About half of people infected with chikungunya virus will progress to a chronic form of the disease. A new study finds that chikungunya virus persists in joint-associated macrophages, a specialized type of white blood cell that helps the body defend against pathogens.
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NewsColorectal cancer risk linked to gut microbiome alterations
A study finds that more than a decade after removal of an adenoma from the colon, the gut microbiome still partly resembles that observed in colorectal cancer (CRC).
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NewsLong Covid burden continues to grow, doubling current surveillance estimates, multi-hospital study shows
Investigators using a novel AI algorithm to comb through medical records of patients with COVID-19 in U.S. hospitals, found around one in six developed long COVID. These rates are twofold higher than current estimates.
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NewsMaternal infection: A critical driver of offspring cardiac dysfunction
A new study reveals that maternal infection causes severe metabolic disturbances within the offspring’s heart, most notably enriching differentially expressed genes in lipid, energy, and amino acid metabolism. The infection also heavily suppressed cardiac cell proliferation.
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NewsHeart health may have impacted the risk of severe COVID-19 infection during the pandemic
Adults with highest heart health scores at the beginning of the pandemic were nearly half as likely to be hospitalized or die from COVID-19 when compared to those with the lowest scores, according to new research.
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NewsGut microbiome clusters may help predict inflammatory bowel disease severity and progression
A new study reports that the gut microbiome of IBD patients can be grouped into distinct compositional “cluster types” associated with disease severity and progression risk. These reflect higher-order microbial community organization rather than variation in individual bacterial species.
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NewsExperimental gene therapy shields brain from toxic protein damage
An experimental gene therapy could help protect the brain from the damage and cognitive decline linked to TDP-43-related proteinopathy, a type of neurodegeneration.
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NewsICU pneumonia has mortality rates of 37% to nearly 60% in middle-income countries. In high-income countries, rates are16% to 26%
A scientific review evaluated outcomes of adults with community-acquired pneumonia (CAP) admitted to intensive care units (ICUs) in middle-income countries. In contrast to high-income countries, where mortality ranges from 16% to 26%, the study found significantly higher rates in the countries analyzed.
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NewsNew study links gut bacteria to immunotherapy success in melanoma patients
Researchers have identified specific gut bacteria linked to better responses to cancer immunotherapy in patients with advanced melanoma. Patients who responded well to treatment were more likely to have a specific type of gut bacteria called Faecalibacterium.
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NewsTrial tests virus-immunotherapy combination for neuroendocrine tumors
A phase I clinical trial is testing whether a tumor-targeting virus can help immunotherapy work more effectively against aggressive neuroendocrine tumors that often resist treatment. The ongoing study has completed its first three dose levels with no severe treatment-related side effects reported to date.