All Disease Treatment & Prevention articles – Page 4
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NewsCurrent antivirals likely less effective against severe infection caused by bird flu virus in cows’ milk
Scientists found that in a preclinical model, two FDA–approved flu antivirals generally did not successfully treat severe H5N1 infections. Meanwhile, the route of infection, whether through the eye, the nose or the mouth, significantly impacts effectiveness.
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NewsNIH-sponsored trial of Lassa vaccine opens
A National Institutes of Health (NIH)-sponsored clinical trial of a candidate vaccine to prevent Lassa fever has begun enrolling participants at the University of Maryland School of Medicine, Baltimore.
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NewsNew CRISPR-based diagnostic test detects multidrug-resistant pathogens in blood without amplification
A highly sensitive amplification-free CRISPR-based diagnostic test is developed to rapidly detect pathogens, including multidrug-resistant bacteria, at low concentrations in blood samples.
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NewsOlder adults might be more resistant to bird flu infections than children
Previous exposures to seasonal flu strains could prime the immune system to produce antibodies against the current version of H5N1 avian influenza virus in older adults, whilst children would benefit more from H5N1 vaccinations.
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NewsFirst coronavirus similar to MERS is found in bats in South America
A novel coronavirus, which shares high genetic similarities with MERS-CoV, was identified in bats in the state of Ceará, Brazil. Experiments to find out whether it can infect humans are set to take place in collaboration with Hong Kong University.
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NewsCOVID-19 discovery opens door to new treatments for chronic lung problems
A discovery was made to understand how severe viral infections, like COVID-19 and flu could destroy the ability of immune cells to repair the tissue damage in lungs, causing long COVID and other chronic lung diseases.
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NewsTecovirimat is safe but ineffective as treatment for clade II mpox
The antiviral drug tecovrimat used without other antivirals did not reduce the time to clinical resolution of clade II mpox lesions or improve pain control among adults in an international clinical trial.
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NewsDrug may prevent COVID-19 in exposed people within households, major trial finds
An international clinical trial of the oral antiviral drug, ensitrelvir, which has been proved to prevent COVID-19 cases, was conducted and found to be very effective. The drug will be awaiting for approval before becoming widely available.
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NewsNew immune mechanism revealed in the cellular trash
The enzyme, proteasomes known for its protein degradation and recycling system, has found to serve another useful purpose that provides promising alternatives for strengthening immune defenses against deadly diseases.
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NewsPrevalence of neutralizing antibodies to AAV2 and AAV9 in individuals with Niemann-Pick disease
A new study shows that more than half of individuals with Niemann-Pick disease, type C1 (NPC1) who were tested lacked neutralizing antibodies against either adeno-associated virus (AAV) 2 or AAV9.
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NewsNew discovery and grant to accelerate Strep A vaccine efforts
With a large sum of research funding and multinational contributions, the world’s only Strep A human challenge model will be used to resolve logistical issues and speed up the development of a successful Strep A vaccine.
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NewsEarly-life gut microbes may protect against diabetes, research in mice suggests
A research discovered that the colonization of a fungus called <i>Candida dubliniensis</i> in the early life gut microbiome of mice, is able to promote growth of pancreatic beta cells in the presence of macrophages to restore blood insulin level and improve metabolic functions, thus reducing risks of type 1 diabetes.
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NewsA 'Trojan Horse' approach to develop new antimalarial drugs
Researchers have discovered a key process whereby malarial parasites take up a human blood cell enzyme, which could provide a new approach for antimalarial treatment.
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NewsNew antibodies show potential to defeat all SARS-CoV-2 variants
Researchers discovered that a paired combination of antibodies binding to the two domains of the SARS-CoV-2 viral particle showed promising results in elimination of all virus variants caused in the COVID-19 pandemic.
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NewsStudy: Smartwatches could end the next pandemic
Everyday smartwatches are extremely accurate in detecting viral infection long before symptoms appear — new research shows how they could help stop a pandemic before it even begins.
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NewsNew test identifies prior infection by zika virus and all four dengue virus serotypes
An alternative approach is developed to detect and distinguish between antibodies induced by the dengue and zika virus in blood samples. The strategy can be used to orient public health policy and evaluate the efficacy of dengue vaccines.
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NewsWorld first clinical trial will study specialized ‘poop pills’ to improve treatment of advanced pancreatic cancer
A world-pioneering fecal microbiota transplantation pill will undergo a clinical trial, aiming to improve immune responses by remodifying the gut microbiome in patients with advance pancreatic cancer.
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NewsGastric bacteria ‘leaking across stomach lining’ could indicate risk of gastric cancer
A new discovery in the roles of gastric microbiota bacteria and Helicobacter pylori across the stomach lining during pre-cancerous stage of gastric cancer development could be the missing link for engineering future therapeutic intervention.
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NewsA*STAR spin-off NalaGenetics implements nationwide drug reaction screening for leprosy patients in Indonesia
NalaGenetics, a spin-off from A*STAR Genome Institute of Singapore (A*STAR GIS), will be transforming leprosy treatments in Indonesia with a nationwide genetic screening programme with their PGx1301 diagnostic kit.
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NewsDesigning self-destructing bacteria to make effective tuberculosis vaccines
Preclinical studies have demonstrated a more effective tuberculosis (TB) vaccine through engineering bacteria to self-destruct and swiftly stops the infection on cue, which activates a more robust immune response.