All Innovation News articles – Page 3
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NewsGolden Gate method enables rapid, fully-synthetic engineering of therapeutically relevant bacteriophages
Researchers have described the first fully synthetic bacteriophage engineering system for Pseudomonas aeruginosa. In this method, researchers engineer bacteriophages synthetically using sequence data rather than bacteriophage isolates.
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NewsBrewing a rare medicine: yeast engineered to produce a valuable astragalus isoflavonoid
By reconstructing the complete biosynthetic pathway inside Saccharomyces cerevisiae and systematically removing metabolic bottlenecks, researchers created the first yeast platform capable of producing calycosin-7-glucoside from simple carbon sources.
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NewsReconstructing nature’s oxindole factory: yeast-based biosynthesis of medicinal indole alkaloids
By identifying four key enzymes from a North American plant and reconstituting them in yeast, scientists have achieved complete de novo biosynthesis of complex oxindole molecules that are difficult to obtain from plants or chemical synthesis.
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NewsEngineered yeast delivers record levels of animal-free chondroitin sulfate
A new study establishes a robust yeast-based platform that overcomes the long-standing trade-off between yield and sulfation, enabling sustainable, high-level production of high-quality chondroitin sulfate without reliance on animal sources.
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NewsEngineering yeast to make rare anticancer saponins: reconstructing the complete biosynthesis of polyphyllin II
By combining plant transcriptomics, enzyme engineering, and synthetic biology, a new study demonstrates, for the first time, the full heterologous production of polyphyllin II in Saccharomyces cerevisiae.
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NewsScientists develop new biosynthetic route to optically pure S-2-Hydroxyisovalerate
By uncovering an unexpected enzyme activity and combining it with precise metabolic engineering, scientists has transformed Escherichia coli into a microbial factory capable of producing gram-per-liter levels of optically pure S-HIV from renewable carbon sources.
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NewsBirding enthusiasts can help songbirds avoid salmonella epidemics
Biologists are developing a tool to predict when deadly salmonella outbreaks are likely to happen in wild songbird populations so that people can protect their feathered friends by taking down bird feeders at the right time.
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NewsProbiotic living microneedles designed by interbacterial competition for accelerated infected wound healing
Probiotic therapy offers a promising strategy for chronic infected wound management. Inspired by bacterial competitive interactions, researchers developed a multifunctional microneedle (MN) platform to overcome the limitations of weak competitiveness and poor penetration across biofilm barriers.
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NewsNew test could help pinpoint IBD diagnosis, study finds
A test that rapidly detects signs of inflammatory bowel disease (IBD) in stool samples could improve future diagnosis and monitoring of the condition, a study suggests. The luminescent reporter lights up when it detects a molecule linked to gut inflammation.
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NewsA gentler way to model deadly lung infections in old age
Researchers report a refined mouse model that successfully mimics chronic Pseudomonas aeruginosa lung infection in old age. The study introduces an agar bead-based delivery strategy that allows bacteria to persist in the lungs of aged mice without causing rapid death.
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NewsInjectable hydrogel-mediated co-delivery of oncolytic adenovirus and melphalan for retinoblastoma control and vision preservation
The collagen-based hydrogel enabled controlled oncolytic adenovirus and melphalan release and sustained retention. This approach eradicated retinoblastoma tumors and restored normal ocular structure and visual function following intravitreal administration.
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NewsSunlight-activated nanospray enables painless, antibiotic-free therapy for infected diabetic wounds
A research team has reported a multifunctional photodynamic nanospray for chronic infected wounds that harnesses natural sunlight to address persistent bacterial infections, impaired healing and severe pain simultaneously.
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NewsFrom palm oil to designer enzymes: researchers reprogram yeast cells
Many everyday products contain fatty acids from palm oil or coconut oil, but the extraction of these raw materials is associated with massive environmental issues. Researchers have now developed a biotechnological approach that could enable a more environmentally friendly production method.
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NewsFrom sediment to surface: How invisible plumes trigger harmful algal blooms
A new study shows that algal blooms can begin days earlier than previously recognized, originating from chlorophyll-rich plumes rising from lake sediments before any surface discoloration appears.
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NewsNew database to target chronic UTIs – a long-overlooked condition that may begin in childhood
A new database targeting chronic urinary tract infections (UTIs) – a long-overlooked condition that may begin in childhood – is set to help researchers uncover why millions of women and girls worldwide suffer from infections that defy treatment and stump microbiologists.
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NewsTurning crop waste into precision weapons against waterborne pathogens
Researchers have developed a novel class of biomass-derived carbon dots that selectively eradicate Staphylococcus aureus in water, using corn straw to synthesize amine-modified nanomaterials that act as oxidase mimics, enabling targeted bacterial inactivation without harming beneficial microorganisms.
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NewsGeneral intelligence framework to predict virus adaptation based on a genome language model
Researchers have developed a viral risk prediction framework named GIVAL based on the pre-trained viral protein language model vBERT.
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NewsSilent dengue infections may hold clues to future vaccine design, study finds
Researchers report the first single-cell immune atlas of asymptomatic dengue, offering a rare look at how the immune system can defeat the virus without triggering illness. The work could help guide the design of safer and more effective dengue vaccines.
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NewsResearchers develop novel tracking method to reveal spread of antibiotic resistance across Hong Kong’s environment
Researchers have harnessed citywide genetic data and developed a novel genome-resolved tracking method to uncover precisely how antibiotic-resistant bacteria and their resistance genes move across Hong Kong’s environment.
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NewsGlobal study to evaluate whether dengue outbreaks can be anticipated earlier
Thousands of dengue forecasting models have been published, but few have been tested in real public-health settings. E-Dengue is a new open-source, user-friendly software system tailored for district-level decision-making.