Innovation – Page 2
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NewsScientists develop shape-shifting scaffold that fights infection and rebuilds bone
Scientists have developed a body-temperature–responsive, 3D-printed shape-memory scaffold coated with a metal–polyphenol network to treat infectious bone defects. It is designed to adapt to irregular bone defects while providing antibacterial activity, immune regulation, and osteogenic support.
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NewsNew tool reveals the secrets of HIV-infected cells
Scientists have developed a novel tool—named HIV-seq—for profiling the features of rare HIV-infected cells from people with HIV. Using the new tool, they’ve found key differences in people’s HIV-infected cells before versus after starting antiretroviral therapy.
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NewsChemically ‘stapled’ peptides used to target difficult-to-treat cancers
Researchers have developed a new technology that uses bacteria to build, chemically stabilise, and test millions of potential drug molecules inside living cells. The bacteria produce vast libraries of peptide molecules, and chemically stabilise them into defined shapes while they are being tested inside the cell.
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NewsNanoparticle vaccine approach takes on a new target: Hepatitis C virus
Scientists have engineered a native-like, stabilized version of Hepatitis C virus’s E1E2 complex and used it to build a nanoparticle-based vaccine candidate. It uses a technology called self-assembling protein nanoparticles, which organizes copies of the proteins into virus-like clusters that the immune system can recognize.
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NewsUltrasound-activated ‘nanoagents’ kill superbugs hiding in biofilms
Scientists have designed nanoagents that act like smart drug‑delivery capsules – carrying an antibiotic deep into bacterial infection sites and releasing it only when activated by gentle ultrasound.
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NewsCell-free DNA offers early warning for bloodstream infections in kids with leukemia
Researchers show that microbial cell-free DNA sequencing can predict bloodstream infections in children with leukemia days before the symptoms appear. Plasma microbial cell-free DNA sequencing (mcfDNA-Seq) offer a potential approach to protecting vulnerable patients by allowing treatment to start before the patient gets sick.
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NewsBacterial cellulose as a sustainable vehicle for the controlled release of nisin and mandelic acid: A clean beauty-based approach for acne treatment
A new study developed a bacterial cellulose-based delivery system loaded with nisin and mandelic acid, targeting acne treatment. Bacterial cellulose, derived from Komagataebacter xylinus, served as a biocompatible, biodegradable matrix to control the release of bioactive compounds.
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NewsSelf-repairing biohybrid system uses sunlight to purify uranium-contaminated water
The efficiency of microbial remediation technologies is often limited by the slow electron transfer rate of microorganisms themselves. Scientists have successfully constructed a novel, self-regenerating “bacteria-mineral” biohybrid system that can utilize light like a solar cell, greatly enhancing the purification efficiency of uranium pollution.
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NewsResearchers engineer bacteria capable of consuming tumours from the inside out
A research team is developing a novel tool to treat cancer by engineering hungry bacteria to literally eat tumours from the inside out. They added a gene to the organism from a related bacterium that can better tolerate oxygen and found a way to activate the oxygen-resistant gene at just the right time.
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NewsNew single-cell transcriptomic clock reveals intrinsic and systemic T cell aging in COVID-19 and HIV
Scientists developed a new single-cell transcriptomic clock called T immune cell transcriptomic clock (Tictock) to measure aging in specific immune cells. They found that in patients with acute Covid-19, the infection increased the biological age of naïve CD8 T cells.
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NewsNovel vaccine protects against C. diff disease and recurrence
A novel vaccination approach cleared the harmful gut bacterium Clostridioides difficile in an animal model of infection. An experimental vaccine administered to the mucosal lining of the colon protected against illness, death, tissue damage and infection recurrence.
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NewsScientists develop first-of-its-kind antibody to block Epstein Barr virus
Using mice with human antibody genes, scientists have developed new genetically human monoclonal antibodies that prevent two key antigens on the surface of the Epstein Barr virus (EBV) from binding to and entering human immune cells.
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NewsNew biosensor offers early warning system for disease
Researchers have developed a tissue-adhesive sensor for real-time oral health monitoring to combat long-term issues such as gum disease and tooth loss.
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NewsA yeast enzyme helps human cells overcome mitochondrial defects
An international team has experimentally uncoupled nucleotide synthesis from mitochondrial activity using ScURA, a yeast-derived genetic tool now available to the research community that will enable new explorations of cellular metabolism.
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NewsRhododendron-derived drugs now made by bacteria
Bioengineered E. coli bacteria can now produce a group of compounds with anticancer, anti-HIV, antidiabetic and anti-inflammatory activities. The compounds, orsellinic acid-derived meroterpenoids, are produced by Rhododendron species.
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NewsImmunity against common virus leveraged against pancreatic cancer
Researchers have discovered a promising new treatment approach for pancreatic cancer. The approach leverages the body’s natural immune response to cytomegalovirus (CMV), a common but typically harmless virus that most people are infected with at some point in their lives.
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NewsResearchers develop new inhalable treatment for TB
Researchers have developed an inhalable, immunomodulating, biocompatible nanoparticle system encapsulating rifampin, one of the most important TB drugs.
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NewsScientists create ‘smart underwear’ to measure human flatulence
Scientists have created Smart Underwear, the first wearable device designed to measure human flatulence. The device helps scientists revisit long-standing assumptions about how often people actually fart. It also opens a new window into measuring gut microbial metabolism in everyday life.
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NewsNew AI model improves accuracy of food contamination detection
Researchers have significantly enhanced an artificial intelligence tool used to rapidly detect bacterial contamination in food by eliminating misclassifications of food debris that looks like bacteria. Current methods often require specialized expertise and are time consuming — taking several days to a week.
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NewsNew algorithm enhances microbiome biomarker discovery by integrating biological relationships
Researchers have developed a novel algorithm, Microbiome Elastic Feature Extraction (MEFE), that significantly improves the identification of microbiome biomarkers by incorporating phylogenetic, taxonomic, and functional relationships among microbes.