All Structural Biology articles – Page 2
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NewsStudy uncovers new kind of cold sensor
Investigators studying a bacterial protein have identified a new mechanism of sensing cold temperatures. The finding points to the possibility that this same type of mechanism exists in other organisms, including humans, and may have relevance for disorders involving faulty temperature regulation.
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NewsResearchers identify potential new route for antimalarial drug design
Researchers have uncovered a promising new potential target for drug discovery. The team focused on an enzyme called aminopeptidase P (PfAPP) from Plasmodium falciparum, the parasite responsible for the most severe form of malaria in humans.
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NewsResearchers uncover three families of ‘sponge’ proteins deployed by phages
Using an innovative research approach that combines artificial intelligence with experimental biology, researchers have uncovered new families of sponge proteins in phage genomes that disrupt immune communication in bacteria.
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NewsScientists uncover how pathogens switch on their virulence
A research team has uncovered how a key protein switches on the machinery that enables Leptospira pathogens to survive and cause disease. The findings provide new insights into how pathogens regulate their virulence and may open new avenues for therapeutic interventions.
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NewsDetailed map of life-threatening Vibrio bacteria reveals new target for treatment
Scientists have mapped in unprecedented detail the structure of Vibrio bacteria, which can cause life-threatening infections linked to antibiotic resistance. The team behind the study say the finding could provide new targets for life-saving treatment.
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NewsTiny switch controls rare rotary machine in bacteria - and can even reverse direction of spin
Researchers have discovered a tiny molecular switch that can control and reverse the direction of a rare rotary machine linked to motility, surface colonization and protein secretion in bacteria.
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NewsNew insights into how bacteria manage DNA
New analytical methods have enabled researchers to uncover how the sequence, physical shape and flexibility of bacterial DNA guide the activity of an enzyme called DNA gyrase, which previously got all the credit for managing DNA.
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NewsScientists find a new way coronaviruses can get into human cells
An international team of researchers has identified an East African bat coronavirus capable of entering human cells. Whilst the virus can bind to a cell receptor found in the human lung, preliminary testing in Kenya suggests it has not spilled over into the local human population.
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NewsScientists catch a fungal enzyme open for business
A new study shows that caspofungin, a widely used antifungal drug, works only when its target enzyme is active, pointing the way toward designing better treatments.
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NewsResearch on tick-transmitted disease reveals potential weakness, opening paths to new treatments
Tularemia is a rare but highly infectious disease caused by Francisella tularensis, a bacterium that can evade immune defenses. Scientists have isolated and studied a set of proteins that play a central role in infection, revealing a potential weakness.
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NewsResearchers disable antimicrobial resistance in cystic fibrosis-associated bacteria
A newly discovered mechanism renders antibiotic-resistant bacteria vulnerable by disabling both their individual resistance and a process known as cross-protection, the ability of resistant bacteria to shield nearby, otherwise sensitive strains.
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NewsA built-in ‘hairpin’ prevents rogue CRISPR RNAs
A new study reveals that many CRISPR-Cas13 systems utilize an RNA to prevent the formation of extraneous CRISPR RNA. With the first repeat, this protective RNA forms a stable structure resembling a hairpin. It points to a remarkable case of convergent evolution.
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NewsUnraveling the complexities of the Borna disease virus 1
Researchers have published the first detailed structural description of the nucleoprotein-RNA complex in the family Bornaviridae. Their observations revealed the three-dimensional structure of this nucleoprotein-RNA complex, showing ring-like assemblies and viral RNA binds in the inner groove.
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NewsNew bite-sized CRISPR molecule may open doors for therapeutic genome editing
The safest, most accurate gene-editing tools don’t fit inside viral delivery mechanisms that could target them to specific cell types or tissues inside the human body. Researchers have developed a smaller pair of “molecular scissors” for gene editing that could make site-specific delivery within the body possible.
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NewsNanodisc platform improves vaccine design for Ebola, HIV and more
Scientists have created a platform that allows viral surface proteins to be studied in a form that more closely resembles how they appear naturally, utilizing nanodisc technology where these proteins are embedded into particles made of lipid molecules, preserving them in a membrane-like structure.
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NewsAtomic-level structure of a giant virus revealed
Researchers have successfully determined, for the first time, the capsid structure of Melbournevirus—a member of the giant virus family—at a resolution of 4.4 Å using cryo-electron microscopy.
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NewsNipah virus hijacks host protein NSUN2 to fuel replication
Researchers have decoded a critical survival strategy of the deadly Nipah virus (NiV), identifying a key host protein hijacked by the pathogen and translating this discovery into a promising new treatment approach.
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NewsHow bacteria outsmart the immune system: Two-pronged strategy revealed
A team has uncovered how a common bacterial pathogen uses a single protein to quietly undermine the human immune system, by both shutting down key warning signals and blocking the cell’s ability to restore them.
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NewsScientists solve 40-year-old biological mystery behind sleeping sickness
Scientists have cracked a 40-year-old biological cold case by revealing how the parasite that causes sleeping sickness stays one step ahead of the human immune system.
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NewsFluorescent imaging reveals how a global parasite develops, opening new paths for drug treatment
Researchers adapted a fluorescent imaging system typically used to study human cells, enabling real-time observation the parasite’s growth, a promising breakthrough against an organism that that infects both humans and animals.
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