A groundbreaking study from the Chinese Academy of Sciences reveals how the traditional herb Picria fel-terrae (PFL) can significantly improve fish health. When added to fish feed at just 0.1% concentration for six weeks, the herb maintained healthy gut structure while reducing inflammation, a common problem in farmed fish.
“Our findings show this ancient herb can simultaneously protect intestinal health, balance immune responses, and improve metabolism,” said Prof. Xiao-Qin Xia, lead researcher. “This could revolutionize how we maintain fish health in aquaculture without relying on antibiotics.”
The research team made several key discoveries. PFL-treated fish maintained healthy gut villi structure while untreated fish developed atrophy. The herb increased protective mucus-producing cells by 30% and reduced harmful inflammation while boosting beneficial immune cells. When challenged with pathogens, fish receiving PFL showed better survival rates.
Surprisingly, the herb worked through multiple pathways, regulating genes involved in immunity, metabolism, and cell repair. It also restored healthy gut bacteria that are typically disrupted by plant-based feeds.
Health challenges
“This is one of the first comprehensive studies showing how a single natural compound can address multiple health challenges in aquaculture,” Prof. Xia noted. The team used advanced techniques, including gene analysis, 3D imaging, and microbiome sequencing, to uncover these effects.
The findings, published in Water Biology and Security, come at a crucial time as the aquaculture industry seeks sustainable alternatives to antibiotics and ways to improve fish nutrition.
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