All Immunology articles
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News
Scientists uncover genes that contribute to severe COVID-19 susceptibility
Researchers confirmed the central and already known role of the TLR7 gene in severe courses of the disease in men, but were also able to find evidence for a contribution of the gene in women.
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Prenatal Zika infection has long-term immune consequences in children, even without microcephaly
New findings challenge the current diagnostic criteria for congenital Zika syndrome, expanding the definition beyond skull or brain abnormalities.
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Study identifies unpredicted immune responses to adenoviral COVID vaccines
Researchers have identified unpredicted T-cell immune responses to the adenoviral (Oxford/AstraZeneca and Janssen) COVID-19 vaccines, but not to the mRNA vaccines.
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Study shows promise for a universal influenza vaccine
New research reveals a promising approach to developing a universal influenza vaccine — a so-called “one and done” vaccine that confers lifetime immunity against an evolving virus.
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Study identifies protein that helps COVID-19 virus evade immune system
Discovery of a new viral evasion mechanism, and of a monoclonal antibody that subverts it, is an advance in immunotherapy that offers the prospect of effective host-directed treatment to combat infections.
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Early life antibiotic increases risk of asthma: providing clues to a potential prevention adult asthma
Early exposure to antibiotics can trigger long term susceptibility to asthma, according to researchers who isolated a molecule produced by gut bacteria that in the future could potentially be trialed as a dietary supplement for children at risk of asthma.
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Respiratory bacteria ‘turns off’ immune system to survive
Researchers have identified how a common bacterium is able to manipulate the human immune system during respiratory infections and cause persistent illness.
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Hepatitis C leaves ‘scars’ in immune cells even after successful treatment
Researchers have discovered that traces of ‘epigenetic scars’ remain in regulatory T cells and exhibit sustained inflammatory properties long after the Hepatitis C virus is cleared from the body.
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Scientists discover how to improve vaccine responses to potentially deadly bacterium
Researchers have shown in an animal model that targeting a key suppressive immune molecule (IL-10) during the delivery of a vaccine improves the ability of the vaccine to protect against infection.
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Study backs RSV vaccine safety during pregnancy
Vaccinating mothers against respiratory syncytial virus (RSV) during late pregnancy to protect their newborns is not associated with an increased risk of preterm birth or other poor outcomes, according to a new study.
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Uncovering ‘Blockbuster T cells’ in the gut wins major prize
Kazuki Nagashima developed a method with which to zero in on individual gut bacterium’s impacts on T cells. His work showed that – contrary to what has been thought – some T cells in the gut can interact with multiple bacteria.
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Researchers reveals why recombinant BCG induces a stronger and longer-lasting response
Researchers are working on a more potent version of the BCG vaccine that protects against TB. While the conventional immunizer reduced infection by 90% in experiments with mice, the recombinant BCG increased protection rates to 99%.
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From ‘hit to vial’: Discovery and optimization of a promising vaccine adjuvant
Scientists identified a new and promising adjuvant, dubbed PVP-037 - in principle, this compound can be added to any vaccine to enhance its action.
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Cancer drug could be repurposed to fight Covid-19
Twelve years ago, cancer researchers identified a molecule that helps cancer cells survive by shuttling damaging inflammatory cells into tumor tissue. In new research, they show that the same molecule does the same thing in lung tissue infected with COVID-19.
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Scientists unravel life-saving effect of dexamethasone in COVID-19
Researchers have discovered how the cortisone compound dexamethasone influences the impaired inflammatory response to Covid-19 and which patients benefit from it.
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Revealed: new factor associated with the risk of severe COVID-19 in people with obesity
By analyzing samples from obese non-diabetics, researchers found that high blood levels of saturated fatty acids cause pre-activation of innate immune cells that, when infected with SARS-CoV-2, produce elevated levels of inflammatory molecules.
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Common respiratory infections may have protected children from COVID-19, study suggests
Analyzing nasal swabs taken during the pandemic, researchers suggest that the frequent presence of other viruses and bacteria may have helped to protect children from the worst effects of COVID-19 by boosting their immune systems.
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Researchers harness intratumoral microbiome against colorectal cancer
Scientists have established a microbiota-targeted drug delivery system that exhibits high efficiency in colorectal cancer targeting and colon retention.
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Features
Infection, immunity and the One Health response in Indonesia
Infectious diseases (IDs) are a major health issue in Indonesia, as in many tropical low- and middle-income countries (LMICs), placing a significant economic burden on limited resources. Vaccination may have a critical role to play in the prevention of zoonotic infectious diseases.
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Imaging measles fusion process reveals pathway to powerful weapon
Scientists have harnessed an imaging technique called cryo-electron microscopy to show—in unprecedented detail—how a powerful antibody can neutralize the measles virus before it completes the process of fusing into the host cell membrane.