All Immunology articles
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Maternal antibodies in breast milk regulate early immune responses in mouse gut
In mice, maternal antibodies ingested in breast milk in the first week after birth help to regulate immune responses in the newborn gut, according to a new study.
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One universal antiviral to rule them all?
Taking inspiration from a rare mutation that makes people impervious to viral diseases, a researcher is developing a therapy that could bestow this superpower on the rest of us. The mutation causes a deficiency in an immune regulator called ISG15.
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Mount Sinai creates first manual for treating infection-associated chronic illness for clinicians
Mount Sinai has launched the country’s first clinical manual for treating infection-associated chronic illnesses (IACIs). This comprehensive guide, prepared by the Cohen Center for Recovery From Complex Chronic Illnesses, part of the Department of Rehabilitation and Human Performance, will help clinicians better diagnose and care for patients with conditions such ...
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Flu fighters: researchers take a closer look at immune response to influenza
Researchers sought to identify which immune cells in pigs have receptors that are most reactive to influenza. They accomplished this by customizing a technology called single-cell RNA sequencing for pigs to learn more about how a body’s cells operate at a highly detailed level.
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Seventy-year-old Parkinson’s drug shows promise against tuberculosis
A medication developed in the 1950s to treat Parkinson’s disease may offer a powerful new tool in the fight against tuberculosis. The study found that benztropine can dramatically reduce levels of TB-causing bacteria by boosting the body’s natural immune response.
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Scientists trace the evolution of the H5N1 virus
Researchers have discovered that the currently circulating 2.3.4.4b clade of H5N1 has specific mutations in its genome that increase its human adaptive potential.
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What exactly is Long COVID? It depends who you ask
New research finds that the definition of Long COVID varies so widely across published studies that the percentage of people identified as having the condition can differ dramatically, making it harder to treat patients and advance research.
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Researchers identify a potential biomarker for long COVID
Researchers have identified a potential biomarker for long COVID. The study results detail the detection of SARS-CoV-2 protein fragments within extracellular vesicles (EVs) — tiny, naturally occurring packages that help cells share proteins, metabolites, and other materials.
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Malaria vaccine mimics natural immunity with high precision
A detailed analysis reveals one of the reasons why the R21/Matrix-M malaria vaccine works so well: the antibodies generated following vaccination are indistinguishable from those found in people who have been infected by the parasites.
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Early challenges to the immune system disrupt oral health
Researchers identified changes over time in the oral microbiome of children living with HIV, offering insights into how early immune challenges shape not only oral health but also systemic health.
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Scientists develop new approach to fighting many viruses at once
Scientists have developed a research pipeline to fuel the development of “universal vaccines,” that would address broad viral families and mutated viral variants.
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Novel immunologic surveillance study provides new insights into post-pandemic return of respiratory viruses
Non-pharmaceutical interventions such as masking and distancing targeted towards SARS-CoV-2 during the pandemic also decreased circulation rates of and population immunity to common respiratory pathogens in children, a new study shows.
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Investigating regional-specific gut microbial distribution: an uncharted territory in disease therapeutics
A new perspective highlights the critical role of region-specific gut microbial distribution across intestinal segments (e.g., duodenum, colon) in regulating host metabolism and immunity, challenging traditional fecal-centric approaches.
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National study urges expanded vaccine screening in emergency departments
About 49% of people are unaware of one or more vaccines recommended for them. Further, 86% have not received one or more of these vaccines, according to the first national comprehensive vaccine surveillance study conducted in emergency departments.
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RNA immunity: A silent defender against viruses in mammals
Researchers propose that small RNA molecules play a direct and specific role in fighting viral infections in mammals. RNA immunity relies on the base-pairing precision of small RNA fragments, such as microRNAs, to recognize and suppress viral genetic material.
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Sweet disguise: the human body hides RNA with sugar coatings
To our immune system, naked RNA is a sign of a viral or bacterial invasion and must be attacked. But our own cells also have RNA. To ward off trouble, our cells clothe their RNA in sugars, a new study reports.
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Nanoparticles that self-assemble at room temperature could transform vaccine delivery
Researchers have engineered polymer-based nanoparticles that form with a simple temperature shift—no harsh chemicals, no specialized equipment, and no processing needed. They can self-assemble at room temperature and deliver RNA to living cells.
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Why killer cells can lapse into ‘exhausted’ CD8+ T cells that no longer can stem disease
In a detailed study of exhausted T cell subsets researchers show that a transcriptional repressor called Gfi1 is a key regulator of the subset formation of exhausted CD8+ T cells and may offer a key to reducing exhaustion.
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AUN bacteria herald an immune-independent breakthrough
A joint research team has developed a groundbreaking immune-independent bacterial cancer therapy using a novel microbial consortium called AUN (阿吽), composed of two naturally occurring bacteria: a tumor-resident microbe and photosynthetic bacterium.
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Smart wound monitor poised to improve chronic infection care
Researchers have developed a wearable wound monitoring device with integrated sensors that could reduce infection risks by minimising the need for frequent physical contact.