All Immunology articles – Page 3
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NewsMicrobe exposure may not protect against developing allergic disease
The “hygiene hypothesis” suggests exposure to diverse types of microbes may protect against developing diseases caused by allergens, but a new study in mice reveals that adults’ exposure to diverse microbes and allergens may in fact worsen certain allergic conditions.
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NewsScientists engineer ‘living eye drop’ to support corneal healing
A proof-of-concept study demonstrates that the harmless eye-dwelling microbe Corynebacterium mastitidis can be genetically modified to secrete an anti-inflammatory therapeutic that promotes healing following corneal injury in a mouse model.
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NewsNew study reveals how hygienic honey bees show unique advantages in fighting infectious pathogens in adult bees
For the first time, research shows that a key social trait in honey bees is linked to measurable physiological advantages that can improve colony survival. The study uncovers how hygienic honey bee colonies mount stronger individual immune defenses against Nosema ceranae.
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NewsHow microbes protect the lungs against allergies
A study has revealed that microbes protect the lungs from subsequently developing allergies and asthma. This long-term protection is “memorized” not by immune system cells but by fibroblasts, structural cells in the lungs.
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NewsFrom gut to lung: A microbial signal that strengthens early immune defense
Researchers report that a gut microbiota–derived metabolite can directly shape immune responses in bacterial pneumonia. Using a Klebsiella pneumoniae infection model, the team demonstrated that butyric acid restores the function of CX3CR1-positive natural killer cells.
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NewsTargeting the gut–lung microbiome to reduce infections in severe pancreatitis
Researchers report new clinical evidence that a fungal probiotic may reduce hospital-acquired infections in patients with severe acute pancreatitis. Patients receiving Saccharomyces boulardii alongside standard enteral nutrition experienced significantly fewer infections than those receiving nutrition alone.
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NewsResearchers identify ‘neuroimmune signature’ that can predict viral hepatitis complications
A network of genes linked to the nervous and immune systems can predict cancer risk and even explain symptoms such as fatigue and depression resulting from viral hepatitis infection.
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NewsScientists develop shape-shifting scaffold that fights infection and rebuilds bone
Scientists have developed a body-temperature–responsive, 3D-printed shape-memory scaffold coated with a metal–polyphenol network to treat infectious bone defects. It is designed to adapt to irregular bone defects while providing antibacterial activity, immune regulation, and osteogenic support.
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NewsBacteria found in mouth and gut may help protect against severe peanut allergic reactions
One of the big mysteries in food allergy is why two people with similar levels of peanut specific antibodies can react so differently. A new study shows for the first time how gut bacteria break down parts of an allergenic food and influence how a person reacts to peanuts.
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NewsStudy finds natural fungal supplement improves COVID-19 vaccine response
Researchers have found that a natural fungal supplement taken at the time of COVID-19 vaccination reduced short-term vaccine side effects and helped antibodies last longer in people who had not previously been exposed to the virus.
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NewsEditing for timing, not overdrive: A new genetic route to fire blight resistance in apple
Fire blight remains one of the most destructive bacterial diseases threatening global apple production. A new study identifies a family of inducible lectin genes, MdAGGs, as critical components of apple immune defense and demonstrates that their precise activation timing is key to effective resistance.
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NewsNanoparticle vaccine approach takes on a new target: Hepatitis C virus
Scientists have engineered a native-like, stabilized version of Hepatitis C virus’s E1E2 complex and used it to build a nanoparticle-based vaccine candidate. It uses a technology called self-assembling protein nanoparticles, which organizes copies of the proteins into virus-like clusters that the immune system can recognize.
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NewsScientists identify therapeutic target that would curb the spread of coronaviruses
Coronaviruses not only use the machinery of the human cells they infect: they modify it to achieve optimal conditions to produce viral proteins and thus spread more quickly, according to a study identifying enzymes that modify transfer RNAs as key elements for coronavirus infection.
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NewsEpigenetic rewiring fuels potato susceptibility to late blight
Scientists performed whole-genome bisulfite sequencing and RNA sequencing on the widely cultivated potato cultivar Qingshu No.9 following Phytophthora infestans infection, uncovering dynamic DNA methylation shifts that correlate with large-scale transcriptional reprogramming and immune suppression.
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NewsStudy reveals immune blueprint for next-generation malaria vaccine
New research has uncovered how the human immune system fights Plasmodium vivax, paving the way for the first effective vaccine against the most widespread form of malaria. It provides critical evidence of how protective immunity to P. vivax works, identifying specific targets on the parasite.
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NewsProtein interplay offers insights into how the immune system recognizes viral RNA
A new study reveals how two proteins cooperate in a key early step of antiviral detection. Using cryo-electron microscopy and high-speed atomic force microscopy, researchers found that LGP2 binds to viral RNA and recruits MDA5 molecules, as if threading beads on a string.
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NewsPeople’s gut bacteria worse in areas with higher social deprivation
Living in a poorer neighbourhood in the UK could impact the make-up of your gut microbiome, potentially leading to worse health. New research found that people living in areas of higher social deprivation have a less diverse range of bacteria in their gut.
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NewsDiffering immune responses in infants may explain increased severity of RSV over SARS-CoV-2
Reseachers report that the two respiratory viruses trigger different immune responses. Those differences might explain why these two diseases have different clinical outcomes and require different treatment strategies.
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NewsMeningococcal B vaccination does not reduce gonorrhoea, trial results show
Contrary to existing evidence from observational studies, the meningococcal B vaccine (4CMenB) has no effect on preventing the acquisition of gonorrhoea, according to the results of the world’s largest randomised control trial (RCT) into possible efficacy.
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NewsHow citrus rewires its vascular system to fight Huanglongbing
By profiling thousands of individual cells, researchers mapped how different vascular cell types in citrus roots respond during early stages of infection with Candidatus Liberibacter asiaticus, revealing profound changes in cell fate, gene expression, and tissue differentiation.