All Immunology articles – Page 2
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Careers
How structural imaging is revolutionising vaccines
Dr. Peijun Zhang, Director of the Electron Bio-Imaging Centre (eBIC) at the UK’s national synchrotron facility Diamond Light Source, reveals how Cryo-ET is powering some of the most important advances in vaccine research.
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News
Ancient remains reveal how a pathogen began to use lice – not ticks – to infect humans
Researchers have analysed ancient DNA from Borrelia recurrentis, a type of bacteria that causes relapsing fever, pinpointing when it evolved to spread through lice rather than ticks, and how it gained and lost genes in the process.
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Tuberculous meningitis: study shows that metabolism drives mortality
A new study suggests that dysregulated β-oxidation may be an important and potentially modifiable contributor to mortality in tuberculous meningitis.
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Post-COVID syndrome: new insights into connection between gut health and fatigue
A new study shows that post-COVID syndrome patients have altered inflammatory markers and a disturbed intestinal barrier, which could contribute to the development of post-viral fatigue.
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A gene variant increases the risk of long COVID
An international team of researchers has found a genetic link to long-term symptoms after COVID-19. The identified gene variant is located close to the FOXP4 gene, which is known to affect lung function.
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Organoids reveal the secrets of bat immunity
Researchers successfully infected both bat organoids and human airway organoids with the Marburg virus. Compared to the human models, bat organoids exhibited a significantly higher baseline antiviral immune activity even before infection.
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Selenium exposure during pregnancy may reduce childhood streptococcal infections
Higher maternal selenium levels during pregnancy were associated with a lower risk of streptococcal infections in children, a new study shows, suggesting a potential protective effect.
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Blood eosinophil count is associated with Pseudomonas aeruginosa infection but not the efficacy of inhaled tobramycin
A study has demonstrated that blood eosinophil counts (BECs) correlate with the disease severity, lung function, exacerbations in bronchiectasis, a chronic airway suppurative disease.
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Cold sore viral infection implicated in development of Alzheimer’s disease
Symptomatic infection with the virus responsible for cold sores around the mouth–herpes simplex 1, or HSV-1 for short—may have a key role in the development of Alzheimer’s disease, suggests a large pharma industry-funded US study.
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Scientists uncover key clues to how a viral infection can lead to arthritis-like disease
By studying Chikungunya virus, scientists have shed light on how immune responses to viral infections may lead to persistent symptoms of autoimmune disease.
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Survival trick: Pathogen taps iron source in immune cells
The body defends itself against pathogens by depriving them of vital iron. However, researchers have discovered that Salmonella bacteria specifically target iron-rich regions within immune cells to replicate, evading the immune defense.
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Common drugs can help viruses spread
JAK inhibitors are often prescribed for autoimmune diseases and inflammatory conditions such as rheumatoid arthritis, but scientists have found they also weaken the body’s natural defences against viruses.
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How the Epstein-Barr virus promotes its spread within the body
Researchers have discovered that the Epstein-Barr virus (EBV) increases the ability of infected immune cells to migrate. In this way, the pathogen promotes its spread in the body – a discovery that may have therapeutic implications.
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Study probes why patients with mitochondrial disease are more susceptible to infections
A new study shows that damaged mitochondria put the immune system in a constant state of alert, leading to dangerous overreactions when patients with rare mitochondrial diseases encounter bacteria.
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Novel molecular maneuver helps malaria parasite dodge the immune system
Researchers have discovered how a parasite that causes malaria when transmitted through a mosquito bite can hide from the body’s immune system. Plasmodium falciparum can shut down a key set of genes, rendering itself “immunologically invisible.”
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New treatment targets link between viral infection and Alzheimer’s disease
A unique mechanism triggering Alzheimer’s disease draws attention: viral infection—while ALT001 is confirmed to alleviate neuroinflammation and suppress viral replication.
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Particles carrying multiple vaccine doses could reduce the need for follow-up shots
Researchers are working to develop microparticles that can release their payload weeks or months after being injected. This could lead to vaccines that can be given just once, with several doses that would be released at different time points.
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Two HIV vaccine trials show proof of concept for pathway to broadly neutralizing antibodies
A new study combining data from two separate phase 1 clinical trials shows that a targeted vaccine strategy can successfully activate early immune responses relevant to HIV, and, in one trial, further advance them.
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Scientists find two brain biomarkers in long COVID sufferers may be what’s causing brain fog
A new study that compares inflammation and brain stress responses in long COVID-19 patients with individuals who have fully recovered shows those with cognitive issues have a lower ability to adapt to stress and higher levels of inflammation in their brains.
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Yellow fever vaccination: how strong immune responses are triggered
Researchers have shown how specific immune cells are activated by the vaccine – an important starting point for the development of new vaccines.