All Immunology articles – Page 2
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NewsPopular GLP-1 drug may slow down biological aging in people with HIV
A new study provides the first randomized, placebo-controlled clinical evidence that semaglutide, a widely used GLP-1 drug, slows down the accumulation of biological aging markers in the DNA of adults with HIV.
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NewsBiomaterial made from jackfruit latex is a promising treatment for periodontitis
Researchers have developed a biomaterial containing jackfruit latex, pomegranate peel extract, and simvastatin that shows promising efficacy in treating periodontitis. This chronic inflammatory disease of infectious origin leads to the progressive destruction of the tissues supporting the teeth, resulting in bone resorption and loss of attachment.
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NewsStudy identifies serious infection risks linked to targeted cancer therapies
A major real-world study has found serious blood-related side effects associated with antibody-drug conjugates, an increasingly important class of targeted cancer therapies. Some ADCs were associated with substantial rates of severe neutropenia – dangerously low levels of infection-fighting white blood cells – and related complications.
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NewsNew study identifies key warning signs for infection after ankle fracture surgery in older patients
A new study of which patients are most at risk of a fracture-related infection post ankle surgery finds that low protein levels in the blood is the single strongest patient-related risk factor, making infection nearly 18 times more likely. Chronic alcohol abuse and failure to follow post-operative instructions each raise the risk more than fivefold.
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NewsBehind the diagnosis: How laboratory testing guided a complex histoplasmosis case
A diagnosis of histoplasmosis forced a teenager with juvenile arthritis onto an uncertain path, one defined by months of treatment, recovery, and a long-term course of antifungal therapy expected to last up to three years. Histoplasma capsulatum, a dimorphic fungus that causes histoplasmosis, found its way into her lungs.
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NewsPost-discharge antibiotics may offer limited benefit after pediatric appendicitis
Acute appendicitis is one of the most common surgical emergencies among children, and complicated acute appendicitis (CAA), including perforated or gangrenous disease, carries a higher risk of infection and longer hospitalization. While intravenous antibiotics during hospitalization are standard practice, the role of oral home antibiotics (OHA) after discharge remains controversial. ...
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NewsHealth researchers call for support to develop pandemic prevention
The Vanderbilt Center for Antibody Therapeutics has received large-scale government grants and contracts to fund the discovery of human antiviral antibodies. The problem is the next step — finding corporate partners to develop the antibodies through human testing.
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NewsResearchers identify immune ‘energy signature’ linked to tuberculosis protection
Researchers found that circulating monocytes from people with latent TB remain metabolically flexible, allowing them to mount strong antibacterial responses, whereas cells from people with active TB disease show impaired metabolism and weaker responses to infection.
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NewsWhy antibiotics fail against a common dental implant disease
A study of peri-implantitis found that bacteria corrode implants, causing them to shed microscopic titanium particles into the surrounding tissue. Those particles hijack the immune cells sent to clear the infection and lock them into a state of inflammation that destroys the jawbone they are supposed to protect.
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NewsExperimental HIV vaccine achieves a long-sought goal
In a first for the field, all non-human primates given a new series of vaccines generated antibodies capable of fighting multiple strains of HIV. It brings researchers closer to a vaccine effective against the vast diversity of HIV strains circulating worldwide.
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NewsScientists validate a link between autoimmunity in a subset of people with long COVID
A research team has demonstrated that autoimmunity, where the body’s immune system attacks its own tissues, is responsible for the often-debilitating and confounding symptoms of long COVID in a subset of people.
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NewsArchaic DNA may lower defences against common DNA viruses in people today
Researchers explored the contribution of archaic DNA - primarily Neandertal ancestry - to the DNA viral load of participants in the UK Biobank. By analysing viral sequences detected in large-scale genomic data, they asked whether archaic variants correlate with the presence or quantity of common DNA viruses.
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NewsResearchers may now understand why chikungunya virus infections turn chronic
About half of people infected with chikungunya virus will progress to a chronic form of the disease. A new study finds that chikungunya virus persists in joint-associated macrophages, a specialized type of white blood cell that helps the body defend against pathogens.
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NewsScientists fight antimicrobial resistance by treating diseases with human antibodies
In a review, researchers highlight the promise of using human monoclonal antibodies (mAbs) to treat patients more effectively and tackle AMR. They say AMR needs to be addressed with multiple and differentiated strategies, and vaccines and mAbs are the most promising tools.
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NewsLong Covid burden continues to grow, doubling current surveillance estimates, multi-hospital study shows
Investigators using a novel AI algorithm to comb through medical records of patients with COVID-19 in U.S. hospitals, found around one in six developed long COVID. These rates are twofold higher than current estimates.
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NewsGut microbe found to worsen sepsis by triggering hyperinflammatory immune responses
Researchers have identified a specific gut microbial group that can dramatically worsen sepsis by excessively sensitizing immune cells. Genetically identical mice showed strikingly different infection outcomes depending on the composition of their gut microbiota.
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NewsStudies point to new way to fight potentially deadly Valley Fever
To better understand why Valley Fever spreads in some individuals, researchers found that patients with severe illness had an abnormal immune response. In some cases, the immune system was overactive; in other cases it was underactive.
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NewsNASCAR star’s death shows how sepsis can kill anyone if not caught
Kyle Busch won more races than any driver in NASCAR history. But his own race ended far too soon, cut short by sepsis at the age of 41 after a case of pneumonia.
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NewsNew immune system enhancer extends COVID-19 vaccine protection reducing need for repeated boosters
Researchers demonstrated that pairing the original COVID-19 mRNA vaccine with an adjuvant extended the duration of the vaccine’s protection in mice from a few months up to two years. The combo also showed a more pronounced response against omicron viral components than the vaccine alone.
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NewsNew study links gut bacteria to immunotherapy success in melanoma patients
Researchers have identified specific gut bacteria linked to better responses to cancer immunotherapy in patients with advanced melanoma. Patients who responded well to treatment were more likely to have a specific type of gut bacteria called Faecalibacterium.