All Immunology articles – Page 7
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NewsResearchers identify immune ‘energy signature’ linked to tuberculosis protection
Researchers found that circulating monocytes from people with latent TB remain metabolically flexible, allowing them to mount strong antibacterial responses, whereas cells from people with active TB disease show impaired metabolism and weaker responses to infection.
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NewsWhy antibiotics fail against a common dental implant disease
A study of peri-implantitis found that bacteria corrode implants, causing them to shed microscopic titanium particles into the surrounding tissue. Those particles hijack the immune cells sent to clear the infection and lock them into a state of inflammation that destroys the jawbone they are supposed to protect.
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NewsExperimental HIV vaccine achieves a long-sought goal
In a first for the field, all non-human primates given a new series of vaccines generated antibodies capable of fighting multiple strains of HIV. It brings researchers closer to a vaccine effective against the vast diversity of HIV strains circulating worldwide.
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NewsScientists validate a link between autoimmunity in a subset of people with long COVID
A research team has demonstrated that autoimmunity, where the body’s immune system attacks its own tissues, is responsible for the often-debilitating and confounding symptoms of long COVID in a subset of people.
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NewsArchaic DNA may lower defences against common DNA viruses in people today
Researchers explored the contribution of archaic DNA - primarily Neandertal ancestry - to the DNA viral load of participants in the UK Biobank. By analysing viral sequences detected in large-scale genomic data, they asked whether archaic variants correlate with the presence or quantity of common DNA viruses.
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NewsResearchers may now understand why chikungunya virus infections turn chronic
About half of people infected with chikungunya virus will progress to a chronic form of the disease. A new study finds that chikungunya virus persists in joint-associated macrophages, a specialized type of white blood cell that helps the body defend against pathogens.
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NewsScientists fight antimicrobial resistance by treating diseases with human antibodies
In a review, researchers highlight the promise of using human monoclonal antibodies (mAbs) to treat patients more effectively and tackle AMR. They say AMR needs to be addressed with multiple and differentiated strategies, and vaccines and mAbs are the most promising tools.
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NewsLong Covid burden continues to grow, doubling current surveillance estimates, multi-hospital study shows
Investigators using a novel AI algorithm to comb through medical records of patients with COVID-19 in U.S. hospitals, found around one in six developed long COVID. These rates are twofold higher than current estimates.
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NewsGut microbe found to worsen sepsis by triggering hyperinflammatory immune responses
Researchers have identified a specific gut microbial group that can dramatically worsen sepsis by excessively sensitizing immune cells. Genetically identical mice showed strikingly different infection outcomes depending on the composition of their gut microbiota.
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NewsStudies point to new way to fight potentially deadly Valley Fever
To better understand why Valley Fever spreads in some individuals, researchers found that patients with severe illness had an abnormal immune response. In some cases, the immune system was overactive; in other cases it was underactive.
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NewsNASCAR star’s death shows how sepsis can kill anyone if not caught
Kyle Busch won more races than any driver in NASCAR history. But his own race ended far too soon, cut short by sepsis at the age of 41 after a case of pneumonia.
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NewsNew immune system enhancer extends COVID-19 vaccine protection reducing need for repeated boosters
Researchers demonstrated that pairing the original COVID-19 mRNA vaccine with an adjuvant extended the duration of the vaccine’s protection in mice from a few months up to two years. The combo also showed a more pronounced response against omicron viral components than the vaccine alone.
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NewsNew study links gut bacteria to immunotherapy success in melanoma patients
Researchers have identified specific gut bacteria linked to better responses to cancer immunotherapy in patients with advanced melanoma. Patients who responded well to treatment were more likely to have a specific type of gut bacteria called Faecalibacterium.
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NewsMicrobiome insights may help predict immunotherapy benefit in kidney cancer
City of Hope researchers report that gut microbiome composition may influence how patients respond to immunotherapy combinations in metastatic renal cell carcinoma, pointing to a potential biomarker that could help guide treatment selection in the future. The microbiome is a rising focus at City of Hope, highlighted ...
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NewsBrain inflammation is unlikely to explain persistent long COVID symptoms
A new brain imaging study has found no evidence of widespread brain inflammation in patients suffering from prolonged symptoms after COVID-19 infection. Instead, the most severe long COVID symptoms were associated with increased brain activity in regions involved in mood and emotion.
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NewsScientists harness T cells to help the body fight entire viral families
Scientists have discovered that combining key vaccine ingredients could give the body the tools it needs to fight the entire family of arenaviruses with a single vaccine, protecting against life-threatening infections from Lassa virus, Junin virus, and other arenaviruses with pandemic potential.
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NewsLargest-ever Canadian clinical trial tests ‘poop pills’ to improve immunotherapy for lung cancer
For nearly half of people diagnosed with lung cancer, immunotherapy can slow the disease but not stop it. A clinical trial will pair immunotherapy with fecal microbiota transplantation (FMT) with the goal of safely increasing treatment effectiveness. If successful, it could provide new treatment options for people with lung cancer.
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NewsHost-based antifouling gold nanotube sensor for the selective detection of mechanically sensitive serotonin release in intestinal mucosa
A new study report a stretchable electrochemical sensing platform with high deformation insensitivity and strong antibiofouling capability. The platform enables in situ capture of dynamic small-molecule chemical signals in the gut, and revealed a new mechanism underlying enhanced intestinal mechanosensation under microbe-related stimulation.
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NewsHidden small RNA determines if cholera bacterium can infect humans
Scientists have uncovered what gives Vibrio cholerae, the bacterium that causes cholera, the ability to colonize the human gut. They found that a small RNA embedded within another gene controls where cholera thrives, a discovery that could improve prediction and prevention strategies.
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NewsTargeted therapeutics show promise in fighting off drug-resistant bacteria
A new study shows that when under attack, the body’s immune cells activate a cellular process called ‘mitochondrial fission’ to kill invading bacteria. Researchers found an experimental treatment called an HDAC6 inhibitor can re-activate the mitochondrial fission process in immune cells to fight invading bacteria.