All Immunology articles – Page 7
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BCG does not protect health workers against Covid
A world-leading international trial into the immune boosting benefits of the tuberculosis vaccine, BCG, has found it does not protect healthcare workers against COVID-19.
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Gut bacteria could be behind weaker immune responses to COVID-19 vaccine
Digestion of fucose sugar by bacteria in our digestive tract could be hampering how effectively we respond to the COVID-19 mRNA vaccine.
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Gum disease may lie at the root of some arthritis flare-ups
New research may help to explain why patients with gum disease are less likely to respond to rheumatoid arthritis treatments.
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Researchers reveal why viruses like SARS-CoV-2 can reinfect hosts and evade immune response
Using a tool called VirScan, Brigham investigators found that people produced shared antibody responses to certain regions of the virus, likely leading to selective pressure and new variants that can repeatedly escape detection by prior immunity.
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Microbes that “eat together” may benefit from a shared immunological memory
A new study examines viruses that infect microbes in the deep sea and finds evidence that viruses interact with a far more diverse set of hosts than was previously thought.
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A healthy microbiome may prevent deadly infections in critically ill people
A study finds that gut microbiota and systemic immunity work together as a dynamic “metasystem,” in which problems with gut microbes and immune system dysfunction are associated with significantly increased rates of hospital-acquired infections.
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Common cold gives children immunity against COVID-19
Researchers have identified memory T cells in children’s blood samples taken before the pandemic that react to cells infected with SARS-CoV-2, the virus that causes COVID-19.
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Engineered bacteria track down tumours, then signal the immune cells
Researchers have created a ’bacterial suicide squad’ that targets tumours, attracting the host’s own immune cells to the cancer to destroy it.
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Fungal spores bind to lung cell protein to escape human defences
The pathogenic fungus Aspergillus fumigatus escapes elimination from surface cells of the human lung by binding to a human protein.
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Gut microbes spur immune cells to mend damaged muscles
Researchers have found that gut microbes spur the production of a class of regulatory T cells that play a role in repairing injured muscles and mending damaged livers.
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Boosting gut microbiota helps healing after colorectal cancer surgery
Researchers have shown for the first time in mice that modifying intestinal flora before surgery could reduce postoperative complications in colorectal cancer patients.
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Pseudomonas aeruginosa produces molecule that paralyzes immune system cells
Researchers in France have discovered a mechanism that likely contributes to the severity of Pseudomonas aeruginosa infections, and could be a target for future treatments.
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Careers
The Kulkarni Lab
The Kulkarni Lab works to determine how locally derived complement proteins in the lung can be harnessed to reduce the burden of end-stage lung disease.
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Clinicians ID severe form of mpox with high mortality in people with advanced HIV
An international collaboration of clinicians has identified a severe, necrotising form of mpox with a high mortality in immunosuppressed people living with HIV.
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Microbiota from mum regulates lung immunity in newborns
Researchers have discovered that a type of white blood cells, the γδ T cells, influences the transfer of maternal microbiota during birth and nursing, and impacts the lung immune response in newborns.
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Cellular evidence reveals why men are at higher risk from COVID-19
Researchers from Osaka University provide cellular evidence for the observed differences between the response to COVID-19 infection in male and female patients.
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Viruses that kill cancer cells show promise for triple-negative breast cancer when combined with chemo
Researchers have shared positive results from a phase 2 clinical trial of an oncolytic virus combined with standard chemotherapy in patients with early stage triple-negative breast cancer.
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Study IDs bacterial weapons that could be harnessed to treat human disease
The discovery of ancient immune-fighting machinery in human cells that is derived from bacteria paves the way toward more ‘CRISPR’-like technologies, researchers say.
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ME linked to changes in the gut microbiome and metabolites
Two studies have found that myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is associated with reduced levels in the gastrointestinal microbiome of microbes known to produce the fatty acid butyrate, disruptions that could explain in part how the immune system becomes disrupted in people with ME/CFS.
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Silent flagellin delivers insights into how gut bacteria evade the immune system
Researchers from the Max Planck Institute for Biology Tübingen have identified a new type of flagellin in the human gut, termed ‘silent flagellin’, that binds to the immune receptor Toll-like receptor 5 without inducing a pro-inflammatory response. Their work addresses the long-standing question of how benign gut microbes evade the ...