All Bioengineering articles – Page 2
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NewsGolden Gate method enables rapid, fully-synthetic engineering of therapeutically relevant bacteriophages
Researchers have described the first fully synthetic bacteriophage engineering system for Pseudomonas aeruginosa. In this method, researchers engineer bacteriophages synthetically using sequence data rather than bacteriophage isolates.
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NewsBrewing a rare medicine: yeast engineered to produce a valuable astragalus isoflavonoid
By reconstructing the complete biosynthetic pathway inside Saccharomyces cerevisiae and systematically removing metabolic bottlenecks, researchers created the first yeast platform capable of producing calycosin-7-glucoside from simple carbon sources.
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NewsReconstructing nature’s oxindole factory: yeast-based biosynthesis of medicinal indole alkaloids
By identifying four key enzymes from a North American plant and reconstituting them in yeast, scientists have achieved complete de novo biosynthesis of complex oxindole molecules that are difficult to obtain from plants or chemical synthesis.
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NewsEngineered yeast delivers record levels of animal-free chondroitin sulfate
A new study establishes a robust yeast-based platform that overcomes the long-standing trade-off between yield and sulfation, enabling sustainable, high-level production of high-quality chondroitin sulfate without reliance on animal sources.
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NewsEngineering yeast to make rare anticancer saponins: reconstructing the complete biosynthesis of polyphyllin II
By combining plant transcriptomics, enzyme engineering, and synthetic biology, a new study demonstrates, for the first time, the full heterologous production of polyphyllin II in Saccharomyces cerevisiae.
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NewsScientists develop new biosynthetic route to optically pure S-2-Hydroxyisovalerate
By uncovering an unexpected enzyme activity and combining it with precise metabolic engineering, scientists has transformed Escherichia coli into a microbial factory capable of producing gram-per-liter levels of optically pure S-HIV from renewable carbon sources.
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NewsExploring metabolic noise opens new paths to better biomanufacturing
Engineers investigating fluctuating metabolic activity in microorganisms have developed tools to keep every microbial cell at peak productivity during biomanufacturing.
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NewsProbiotic living microneedles designed by interbacterial competition for accelerated infected wound healing
Probiotic therapy offers a promising strategy for chronic infected wound management. Inspired by bacterial competitive interactions, researchers developed a multifunctional microneedle (MN) platform to overcome the limitations of weak competitiveness and poor penetration across biofilm barriers.
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NewsCommercially viable biomanufacturing: designer yeast turns sugar into lucrative chemical 3-HP
Using a tiny, acid-tolerant yeast, scientists have demonstrated a cost-effective way to produce industial chemical 3-Hydroxypropanoic acid, making disposable diapers, microplastics, and acrylic paint more sustainable through biomanufacturing.
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NewsRibosomal engineering creates ‘super-probiotic’ bacteria
Using ribosome engineering (RE), researchers introduced mutations affecting the protein synthesis mechanism of probiotic Lacticaseibacillus rhamnosus GG (LGG). These mutant LGGs exhibit altered surface protein expression, including increased presentation of so-called “moonlighting proteins.”
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NewsMutated baker’s yeast at the forefront of petroleum substitute tech
Researchers engineering Saccharomyces cerevisiae to produce 2,3-butanediol (2,3-BDO) introduced mutations into the genomic DNA. The researchers engineered four altered strains and subjected them to ethanol, heat, and low pH stressors.
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NewsEngineering oncolytic bacteria as precision cancer therapeutics
A new review summarizes recent advances in the design and application of synthetic biological strategies that enhance bacterial precision, safety, and efficacy in tumor therapy.
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NewsYeast cell factory developed to convert methanol into L-lactate
Researchers developed a yeast cell factory to produce L-lactate from methanol as the sole carbon source, and evaluated the commercial potential and environmental impacts of this bioprocess.
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NewsEngineered virus boosts immune response against glioblastoma in preclinical models
Researchers have modified a herpes simplex virus (HSV-1) that stimulates the immune system to attack glioblastoma cells. A single dose of the modified virus increased T-cell, natural killer cell, and myeloid cell responses in the tumor microenvironment and increased the overall survival in preclinical models.
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NewsDeep sea microbes yield up their engineering secrets
A biomatrix of tiny tubes of protein, known as cannulae, link cells of the thermal vent-dwelling archaeon Pyrodictium abyssi together into a highly stable microbial community. A study reveals new details about the elegant design of the cannulae and their method of construction.
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NewsAlgae show how to make two proteins from one messenger RNA
Scientists have uncovered a hidden feature of protein translation in green algae, offering a new perspective on the basic rules of gene expression.
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NewsScientists develop world’s first modular co-culture platform for the one-pot production of rainbow-colored bacterial cellulose
The team engineered Komagataeibacter xylinus for bacterial cellulose synthesis and Escherichia coli for natural colorant overproduction. A co-culture of these engineered strains enabled the in situ coloration of bacterial cellulose.
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NewsGenetically engineered fungi are protein packed, sustainable, and taste similar to meat
Researchers used CRISPR to increase a fungus’s production efficiency and cut its production-related environmental impact by as much as 61%—all without adding any foreign DNA. The genetically tweaked fungus tastes like meat and is easier to digest than its naturally occurring counterpart.
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NewsResearchers boost biosynthetic capacity in yeast through extended lifespan
Scientists have demonstrated that combining lifespan engineering strategies with metabolic pathway optimization in Saccharomyces cerevisiae enables highly efficient sclareol biosynthesis, marking an advance in improving microbial production through lifespan engineering.
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NewsBacteria ‘pills’ could detect gut diseases — without the endoscope
Researchers report that they’ve developed a sensor made of tiny microspheres packed with blood-sensing bacteria that detect markers of gastrointestinal disease. Taken orally, the miniature “pills” also contain magnetic particles that make them easy to collect from stool. Excreted from mouse models with colitis, the bacterial sensor detected gastrointestinal bleeding within minutes.