All Editorial articles – Page 17
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Topical gel relieved ear infections in animals after just one dose
Researchers report a topical antibiotic gel that, applied once, cured middle ear infection within 24 hours in chinchillas. a single dose of treatment for middle ear infections could improve patient compliance and potentially reduce pediatric antibiotic usage.
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Scientists launch intranasal albumin-based vaccine technology platform against respiratory virus
A new paper reports on a novel vaccine technology platform, in which the subunit antigen is genetically fused to albumin. The albumin-antigen fusion vaccines induced both systemic and mucosal antigen-specific antibody responses.
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New molecular label could lead to simpler, faster tuberculosis tests
Chemists have demonstrated that they can label a glycan called ManLAM using an organic molecule that reacts with specific sulfur-containing sugars. These sugars are found in only three bacterial species, including the microbe that causes TB.
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Placebo-testing vaccines is unethical, ‘a waste of time and money,’ expert says
The proposal to require that all new vaccines undergo safety testing in placebo-controlled trials is ethically problematic and will slow testing down for no good reason, warn scientists.
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Antibodies that recognize lipids: A new path for HIV vaccines and autoimmune disease treatments
Scientists have used computer modeling to illustrate how a specific class of antibodies actually use lipids to recognize the HIV virus. The work highlights antibody features that could help people design better vaccines for HIV and autoimmune diseases.
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Scientists uncover the link between ‘good’ gut bacteria and rheumatoid arthritis
After spending years tracing the origin and migration pattern of an unusual type of immune cell in mice, researchers have shown how activity of “good” microbes in the gut is linked to rheumatoid arthritis and, potentially, other autoimmune diseases.
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$2.7 million NIH grant to fund first comprehensive syphilis test
With a four-year, $2.7 million grant from NIAID, researchers aim to develop a one-step confirmatory laboratory test that can definitively diagnose active syphilis infection within 10 minutes.
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Barriers remain to peptide-based therapies - but there are answers, reveals study
Peptide-based therapies offer the potential to transform how we treat a range of conditions - but have yet to be adopted for widespread clinical use. A new review uncovers the barriers to adoption and identifies ways to overcome these limitations.
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Monoclonal antibody nirsevimab provides strong protection against severe RSV in infants
Nirsevimab, a monoclonal antibody, is highly effective in real-world conditions at preventing severe respiratory syncytial virus (RSV) infections in infants, suggests a meta-analysis.
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A digestive ‘treasure chest’ shows promise for targeted drug treatment in the gut
A new approach to drug design can deliver medicine directly to the gut in mice at significantly lower doses than current inflammatory bowel disease treatments.
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A symbiotic gut fungus wards off liver disease in mice
Researchers have found a new ally in the fight against a serious liver disease: a symbiotic gut-dwelling fungus that produces a molecule shown to be capable of reversing disease progression in mice.
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Designer microbe shows promise for reducing mercury absorption from seafood
Scientists who inserted DNA-encoding methylmercury detoxification enzymes into the genome of an abundant human gut bacterium found it detoxified methylmercury in the gut of mice and dramatically reduced the amount that reached other tissues.
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Study of facial bacteria could lead to probiotics that promote healthy skin
Researchers have revealed the dynamics of interactions between two dominant skin bacterial species in more detail than previously possible, shedding light on when and how new bacterial strains emerge on the skin of the face.
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Hiding in plain sight: Researchers uncover the prevalence of ‘curiosity’ virus
A type of virus thought to be a ‘mere curiosity’ is plentiful in one common bacteria, researchers have found. The discovery improves understanding of how viruses work and could mean telomere phages are also common in other types of bacteria.
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Bacterial villain behind Lake Erie’s ‘potent toxin’ unveiled by study
In Lake Erie, cyanobacteria can proliferate out of control, creating algal blooms that produce toxins that can harm wildlife and human health. Researchers have IDed the organism responsible for the toxins: a cyanobacteria called Dolichospermum.
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Protein sources change the gut microbiome – some drastically
A new study shows that protein sources in an animal’s diet can have major effects on both the population and function of the gut microbiome. The two largest effects of dietary protein were on amino acid metabolism and complex sugar degradation.
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Bacteria deployed as living test tubes to study human gene mutations
Bioengineers have developed a new simple approach to rapidly check on human gene changes and also screen chemicals as potential drugs by turning everyday bacteria into living test tubes.
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New AI technique can uncover antiviral compounds using limited data
Artificial intelligence algorithms have been combined with traditional laboratory methods to uncover promising drug leads against human enterovirus 71 (EV71), the pathogen behind most cases of hand, foot and mouth disease.
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Herpesvirus protein mimics host enzyme to balance infection and latency
Researchers have uncovered a novel regulatory mechanism of CDK mimicry that may help herpesviruses coexist and expand within host cells while balancing host survival with viral persistence throughout the host’s lifespan.
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Long COVID biomarkers found – associated with respiratory problems
Researchers have identified biomarkers in the blood associated with symptoms of long COVID, particularly severe respiratory disorders. The discovery can pave the way for future diagnosis and treatment.