All tuberculosis articles
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NewsNew one-two punch could knock out drug-resistant TB
Researchers found that pairing the antibiotic rifampicin with a second compound turned multidrug resistance into a weakness—providing proof of concept for using basic science to design life-saving dual-drug strategies.
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NewsCould hidden infections be fueling long COVID?
For millions suffering from long COVID, their persistent breathlessness, brain fog and fatigue remain a maddening mystery, but microbiologists think they may have cracked the case. The review argues that co-infections acquired before or during COVID could cause symptoms to persist indefinitely for many people.
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NewsTuberculosis: Scientists develop novel drug candidate for combating resistant pathogens
Researchers have developed a promising new substance for targeting bacteria that cause tuberculosis. The team have produced a compound that inhibits the pathogens’ ability to produce energy and causes them to die.
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News‘Creeping catastrophe’: Climate change is driving global rise in infectious diseases, leading health experts warn
Infectious diseases such as malaria, dengue, and tuberculosis are considered to pose as great a challenge to global health as new or emerging pathogens, according to a study. Participants reported that climate change, poverty, and drug resistance are combining to create an escalating health crisis.
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NewsPhase 2 clinical trial results show potential to shorten TB treatment time
New clinical trial results show that the novel antibiotic candidate sorfequiline (TBAJ-876), a next-generation diarylquinoline, has the potential to improve tuberculosis (TB) treatment when combined with pretomanid and linezolid in a treatment regimen known as “SPaL.”
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NewsScientists uncover tuberculosis bacterium’s ’heartbeat’, opening door to new treatments
Scientists have identified a molecular system inside Mycobacterium tuberculosis that functions like the organism’s heart or lungs, keeping it alive. The system, known as PrrAB, helps the bacterium generate energy and breathe. When researchers used a gene-silencing tool, the bacterium died.
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NewsNew study finds targets for a new tuberculosis vaccine
A large-scale screen of tuberculosis proteins has revealed several possible antigens that could be developed as a new vaccine for TB, the world’s deadliest infectious disease.
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NewsUS funding cuts could result in nearly 9 million child tuberculosis cases, 1.5 million child deaths
A new study projects that US funding cuts to global health aid will have a catastrophic effect on pediatric TB, with children in Sub-Saharan Africa and Southeast Asia likely to experience a spike in preventable cases and deaths over the next decade.
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NewsCould targeted steroid use offer a universal complimentary treatment to fight TB?
Newly published research provides evidence that treating patients with steroids may enhance the function of their macrophages to kill the mycobacteria, while diminishing pathways of inflammatory damage.
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NewsNew global burden of disease study: Mortality declines, youth deaths rise, widening health inequities
The world faces an emerging crisis of higher death rates in adolescents and young adults in North America and Latin America due to suicide and drug and alcohol consumption, and in sub-Saharan Africa due to infectious diseases and unintentional injuries.
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NewsCattle vaccine immunity ‘boost’ tested by new research
Scientists at Aberystwyth University are leading research into how a widely used vaccine can boost overall immunity in livestock. The four-year study will investigate the concept of ‘trained immunity’ – a form of immune memory triggered by a vaccine.
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NewsNew CRISPR test could make tuberculosis screening as simple as a mouth swab
Researchers have developed an enhanced CRISPR-based tuberculosis test that works with a simple tongue swab, a potential breakthrough that could allow easier, community-based screenings for the world’s deadliest infectious disease.
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NewsNew ‘cough simulator’ mimics TB transmission with unprecedented accuracy
Researchers have developed a new experimental system called Transmission Simulation System (TSS) that replicates the airborne transmission of TB – by simulating the human cough – with unparalleled realism and never-before-seen precision.
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NewsNew AI tool reveals how drugs kill tuberculosis
A new study offers a powerful AI-assisted method for uncovering exactly how TB drugs kill the bacteria, opening the door to smarter treatment combinations that could work faster.
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NewsSeventy-year-old Parkinson’s drug shows promise against tuberculosis
A medication developed in the 1950s to treat Parkinson’s disease may offer a powerful new tool in the fight against tuberculosis. The study found that benztropine can dramatically reduce levels of TB-causing bacteria by boosting the body’s natural immune response.
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NewsSkin test reagent proves effective and safe for TB diagnosis in children
A new class of skin test reagents based on Mycobacterium tuberculosis (MTB)-specific antigens has been developed. A phase III clinical trial suggests that C-TST is an effective and safe option for diagnosing pediatric TBI.
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NewsIn hard-to-treat form of tuberculosis, shorter, gentler therapy shows unequal benefit
A first-ever clinical trial exclusively conducted among people with a hard-to-treat form of tuberculosis known as pre-extensively drug-resistant TB shows many patients benefit from shorter, simpler regimens.
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NewsTB bacteria play possum to evade vaccines
Scientists studied how the TB bacterium evades an immune system primed to destroy it. Their genetic study in mice reveals that TB bacteria can essentially play dead to outlast the immune response.
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NewsNew breakthrough uncovers how to kill ‘zombie’ TB cells resistant to antibiotics
Researchers exposed a library of over 500,000 genetically modified tuberculosis bacteria to two commonly used antibiotics. By analysing the survivors, they pinpointed genes whose disruption significantly reduced the number of surviving persisters.
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NewsMultiple testing for infectious diseases among migrants key to cutting onward transmission
Routine testing for multiple infectious diseases among migrants will benefit healthcare systems by identifying key infections earlier, a new study finds.