All Antimicrobials articles – Page 2
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NewsNew antibody–drug conjugate strategy to block HIV infection
New antibody–drug conjugates (ADCs) combine a CD4 mimic with neutralizing antibodies for enhanced suppression of HIV infection. By targeting the gp120 on the viral envelope via a two-step mechanism, the ADCs effectively block viral entry.
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NewsRhododendron-derived drugs now made by bacteria
Bioengineered E. coli bacteria can now produce a group of compounds with anticancer, anti-HIV, antidiabetic and anti-inflammatory activities. The compounds, orsellinic acid-derived meroterpenoids, are produced by Rhododendron species.
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NewsHIV antibody opens up new approaches for vaccine development and combination therapies
An international research team has identified a novel HIV antibody that targets the virus at a particularly vulnerable site and overcomes previous limitations of known antibodies. The study opens up new perspectives for the development of vaccines and therapeutics against HIV-1.
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NewsBack from blight: Genomics offers a faster path to restoring the American chestnut
After more than a century of devastation from deadly blight, the iconic American chestnut tree could be brought back from the brink of extinction thanks to novel genomic tools and carefully bred hybrids, a new study finds.
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NewsStiff gels slow germs: New study maps hydrogel properties that control bacterial growth
Scientists has found that firmer, lower water content hydrogels limit bacterial growth, with implications for designing antibacterial coatings, infection models, and advanced medical materials.
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NewsTechnology transfer for Corallopyronin A successfully completed with Phyton Biotech
Phyton Biotech has successfully transferred the manufacturing process for the microbial production of Corallopyronin A (CorA). CorA is a novel anti-infective agent with the potential to address neglected tropical diseases.
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NewsFrom biocidal coatings to medicines: A nanocomposite sting for microorganisms
A surface capable of responding to chemical signals generated by microorganisms and automatically producing biocidal substances – a description of how the B-STING silica nanocomposite works. The new material acts as a nanofactory of reactive oxygen species, activating only when necessary.
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NewsResearchers demonstrate SARS-CoV-2 virus inactivation/destruction using focused sound waves
A team of researchers has successfully demonstrated the destruction of SARS-CoV-2 virus particles through exposure to high-frequency sound waves, marking a promising advance in non-pharmacological antiviral strategies.
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News‘Trojan horse’ may deliver toxic dose of copper to bacterial colonies, including drug-resistant MRSA infections
A research team is developing a drug that works in combination with copper to kill bacteria, including those that cause MRSA, a type of staph infection that is resistant to usual treatments.
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NewsScientists synthesize medicarpin in baker’s yeast
Scientists have developed a way to synthesize medicarpin in yeast. Like palitaxel in the 1990s, this tumor-attacking sustance has only limited natural quantitites and is considered difficult to synthesize.
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NewsEarly translational study supports the role of high-dose inhaled nitric oxide as a potential antimicrobial therapy
Researchers report that high-dose inhaled nitric oxide (iNO) demonstrates potential antimicrobial activity in preclinical models and is safe and feasible in early human studies, supporting further clinical investigation.
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NewsLiquorice root could be effective against upper respiratory tract infections - while protecting ‘good’ microbes
Lozenges supplemented with liquorice root extract could be an effective remedy against upper respiratory tract infections while protecting microbes that are beneficial to the body, reveals a study presented at MLS Future Forum, which is supported by Applied Microbiology International.
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NewsA protein found in the GI tract can neutralize many bacteria
The mucosal surfaces that line the body are embedded with defensive molecules that help keep microbes from causing inflammation and infections. One of these molecules, intelectin-2, has broad-spectrum antimicrobial activity against bacteria found in the GI tract.
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NewsSunlight-activated nanospray enables painless, antibiotic-free therapy for infected diabetic wounds
A research team has reported a multifunctional photodynamic nanospray for chronic infected wounds that harnesses natural sunlight to address persistent bacterial infections, impaired healing and severe pain simultaneously.
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NewsScientists decode tree genome to unlock terpenoid-based disease resistance
Researchers reported a chromosome-scale genome and multi-omics analysis of a Lauraceae medicinal tree. The study reveals how specific terpene synthase (TPS) genes contribute to antimicrobial compound production and enhanced resistance to plant diseases.
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NewsResearchers revive failing antibiotics with two-faced Janus nanoparticles
Researchers have restored the power of failing antibiotics by combining them with two-sided nanoparticles, ultra-small building blocks of materials less than 100 nanometers across. The nanoparticles showed a remarkable ability to compromise bacterial cell walls, leaving them vulnerable to attack.
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NewsPlant-derived phenolic acids revive the power of tetracycline against drug-resistant bacteria
A study demonstrates that plant-derived phenolic acids can act as powerful antibiotic adjuvants by restoring and enhancing tetracycline efficacy against multidrug-resistant bacteria through multi-target disruption of key resistance mechanisms.
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NewsResearchers develop novel composite copper oxides with strong and stable antiviral activity
Composite copper–lanthanum and copper–yttrium oxides developed by researchers from Japan demonstrate exceptionally high antiviral activity against non-enveloped virus. These oxides are highly stable and achieve over 99.999% viral inactivation in laboratory tests.
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NewsNew antimalarial drug candidate shows potential for fighting resistance and reducing malaria transmission
Researchers have developed a new antimalarial drug candidate designed to address the growing challenge of drug resistance and potentially reduce malaria transmission.
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NewsScalable nanoengineered gauze with sustained natural product release
A multi-institutional Chinese research team has developed PPCZ@Gauze – a novel nanoengineered dressing that synergistically combines antibacterial, anti-adhesive, and pro-angiogenic functions.