All Clinical & Diagnostics articles
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NewsResearchers develop next-generation CRISPR biocontainment technology for controlling microbial survival without DNA cleavage
Researchers have employed a CRISPR-dCas9-based base editing system capable of introducing precise nucleotide changes without inducing DNA double-strand breaks. The researchers targeted the start codons of essential genes and irreversibly disrupted their function, permanently blocking cell survival.
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NewsPregnant women’s mental images are directly linked to vaccine hesitancy and uptake
When pregnant women think about vaccinations, many experience vivid mental images – such as a sick baby in hospital – that have a direct link to their opinion of the vaccine and whether they ultimately have it, new research has shown.
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NewsExpanded tuberculosis screening does not speed up treatment initiation or improve survival in hospitalized patients with HIV
According to the EXULTANT trial, adding molecular tests on sputum, urine and stool samples does not appear to outperform the standard WHO-recommended diagnostic approach.
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NewsTuberculosis risk: promising approaches for screening and prediction
It is currently difficult to detect TB in its early stages, or predict who will go on to have TB, and therefore preventive treatment is not widely used. Researchers assessed whether a blood-based 3-gene host-response test can detect active tuberculosis and help predict future disease.
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NewsLong-term dynamic virological response patterns and clinical outcomes in hepatitis B virus-related cirrhosis
The long-term clinical outcomes of patients with hepatitis B virus (HBV)-related cirrhosis receiving nucleos(t)ide analog (NA) therapy according to virological response patterns remain inadequately defined. A new study aimed to investigate the association between virological response patterns and clinical outcomes.
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NewsResearchers find diagnostic delays are common for US pediatric patients with malaria
Researchers found that more than one in four pediatric patients treated for malaria in the United States had a delay in their initial diagnosis, increasing the risk of more severe infection.
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NewsResearchers flip the CRISPR script to develop world’s first DNA-guided gene editing tool for precise infectious disease diagnosis
A research team has successfully developed the world’s first DNA-guided CRISPR-Cas system capable of programmable RNA targeting and cleavage. This breakthrough overturns the conventional CRISPR paradigm, which uses RNA as a guide to target DNA.
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NewsPolymer ‘bristles’ could help repel proteins — and germs — from surfaces in medical settings
A non-toxic coating made of polydimethylsiloxane prevents proteins from sticking to surfaces — potentially offering a new tool in the fight against hospital-acquired infections.
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NewsStudy identifies multiple viruses and variants simultaneously by controlling the “speed” of CRISPR gene scissors
Scientists have developed a new diagnostic technology that simultaneously identifies various viruses and variants by controlling the “speed” of gene scissors.
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NewsTeam discovers gene pattern that could help doctors identify Ebola faster and more accurately
Researchers have made an important discovery that could help doctors tell Ebola apart from other infections more quickly. The overlap of response by Ebola and other pathogens had made it difficult to find markers that are truly unique to Ebola.
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NewsPortable TB test matches lab accuracy in just minutes
A portable device called MiniDock MTB can deliver accurate TB test results in less than half an hour. Researchers show the device is as effective as a laboratory test and can detect cases even among people who have trouble producing phlegm samples from deep within their lungs.
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NewsPhage therapy at a turning point: Valencia 2026 to define the next era of antibacterial medicine
The Targeting Phage Therapy 2026 Congress will bring together leading scientists, clinicians, microbiologists, engineers, biotech leaders, regulators, hospital teams, start-ups, and innovators to ask: How can phage therapy move from promising science to accessible, validated, and deployable medicine?
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NewsCOVID-19 and severe heart attack increase mortality by 25% after one year, more than double pre-pandemic rates
Findings from the North American COVID-19 Myocardial Infarction (NACMI) registry demonstrate significantly higher one-year mortality rates in patients with COVID-19 and ST-elevation myocardial infarction (STEMI) compared to patients with STEMI alone.
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NewsCinnamic acid blocks plasmid conjugation to slow antibiotic resistance spread
A new study reveals that cinnamic acid, a widely used food additive found in cinnamon, can effectively inhibit plasmid‑mediated conjugation, a major route for the global spread of antibiotic resistance genes (ARGs).
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NewsIntestinal Candida albicans is associated with subclinical coronary atherosclerosis in metabolic dysfunction-associated steatotic liver disease with cirrhosis
Researchers have published the first report of gut fungal dysbiosis associated with the severity of metabolic dysfunction-associated steatotic liver disease and subclinical coronary atherosclerosis. An increased abundance of fecal C. albicans was observed in patients with cirrhosis and high SCA burden.
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NewsEight-year results from two randomized phase 3 trials of tenofovir alafenamide for chronic hepatitis B virus infection in China
Tenofovir alafenamide (TAF) has demonstrated comparable efficacy to tenofovir disoproxil fumarate (TDF), with improved renal and bone safety, in Chinese participants with chronic hepatitis B enrolled in two Phase 3 trials.
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NewsCOVID antiviral speeds recovery but doesn’t reduce hospitalization in vaccinated patients, trials find
Paxlovid (nirmatrelvir-ritonavir) does not reduce hospital admissions or deaths in vaccinated adults at higher risk of severe COVID-19, despite helping them recover faster, according to results from two national trials.
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NewsIBS treatment response predicted by gut microbiome in new study
Researchers investigating irritable bowel syndrome with diarrhea observed distinct characteristics of patients’ gut microbiomes that predicted whether they responded to the low FODMAP diet or rifaximin — or did not respond to treatment.
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NewsResearchers combine polarized light and a magnetic field to spot malaria under the microscope
Researchers have developed a new microscopy method that uses a magnetic field and polarized light to provide quantitative measurements that could enable faster and more objective detection of malaria in blood.
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NewsGut microbiome changes may signal Parkinson’s disease risk
Scientists have found that people with Parkinson’s disease have a distinctive makeup of gut microbes, as do healthy individuals who are genetically at risk of Parkinson’s disease. This could help to develop tests to reveal a person’s risk of developing Parkinson’s disease.