All Clinical & Diagnostics articles – Page 2
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Long ReadsRethinking Blastocystis: a One Health perspective on a common and controversial gut protist worth our attention
Here’s the reality: a stool report that reads “Blastocystis detected” still provokes strong reactions. Some clinicians worry and reach for antibiotics. Some laboratories add a note about “uncertain significance.” Patients search online and find polarised claims ranging from harmless commensal to stealth pathogen. The truth is more nuanced and more ...
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NewsGut health home-testing kit outcomes vary between kits and manufacturers
Results and health assessments from gut microbiome home-testing kits vary whether they are produced by the same or different manufacturers. The findings on testing kits from seven providers highlight the need for caution when interpreting or acting on test results, according to the authors.
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NewsSingle daily pill shows promise as replacement for complex, multi-tablet HIV treatment regimens
A phase 3 clinical trial has shown that a new, daily oral tablet that combines two current HIV treatment medications – bictegravir and lenacapavir (BIC/LEN) – may simplify treatment significantly for people with HIV who currently take very complex treatments.
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NewsUrinary tract infections can trigger delirium and worsen dementia
Urinary tract infections can pose serious risks for older adults, particularly those with Alzheimer’s disease and other forms of dementia. In older patients, a common UTI can trigger delirium, a medical emergency marked by sudden confusion and altered awareness.
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NewsNew study finds sex and menopause-based differences in presentation of early Lyme disease
In a new study, researchers found that male and female patients with early Lyme disease present with different signs of the disease in the symptoms they report, their physical exams and their laboratory test results.
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NewsScientists find that silencing bacteria can worsen heart infections
By studying a bacterium responsible for a severe heart infection, the scientists show that disrupting bacterial communication can be associated with adverse clinical outcomes. These findings open the door to more targeted therapeutic strategies against this type of infection.
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NewsFirst evidence of fungal pathogen becoming more deadly when co-infected with tuberculosis
Co-infection of Mycobacterium tuberculosis, together with Cryptococcus neoformans, is a grave public health concern, increasing the risk of death significantly. Researchers have found that in the presence of Mycobacteria, the fungus changed its cell density, cell diversity, and capsule size.
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NewsNew single-cell transcriptomic clock reveals intrinsic and systemic T cell aging in COVID-19 and HIV
Scientists developed a new single-cell transcriptomic clock called T immune cell transcriptomic clock (Tictock) to measure aging in specific immune cells. They found that in patients with acute Covid-19, the infection increased the biological age of naïve CD8 T cells.
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NewsScientists home in on Acinetobacter baumannii’s resistance evolution
Scientists have found a way to understand how Acinetobacter baumannii is evolving - and how best to strategize a fight against it. They have produced a huge whole-genome look at the rise of this resistance, pointing the way to new strategies in staying ahead of the pathogen.
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NewsComplexity key to preventing infection after heart surgery
Research indicates that uniform materials could be the culprit behind deadly infections that can occur when using synthetic materials for cardiovascular grafts.
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NewsCOVID-19 vaccination during pregnancy may help prevent preeclampsia
A new multinational study has found that COVID-19 vaccination during pregnancy, particularly when combined with a booster dose, significantly reduces the risk of preeclampsia, a serious and potentially life-threatening pregnancy complication.
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NewsNew antibody–drug conjugate strategy to block HIV infection
New antibody–drug conjugates (ADCs) combine a CD4 mimic with neutralizing antibodies for enhanced suppression of HIV infection. By targeting the gp120 on the viral envelope via a two-step mechanism, the ADCs effectively block viral entry.
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NewsNew clinical guidelines to reduce central line-associated bloodstream infection
Central line-associated bloodstream infections remain a major challenge in ICUs. A team of clinicians has proposed updated guidelines to standardize the clinical practices addressing CLABSI, aiming to reduce infection rates and improve outcomes for critically ill patients.
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NewsNew biosensor offers early warning system for disease
Researchers have developed a tissue-adhesive sensor for real-time oral health monitoring to combat long-term issues such as gum disease and tooth loss.
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NewsHPV cancer vaccine slows tumor growth, extends survival in preclinical model
Scientists discovered that systematically changing the orientation and placement of a single cancer-targeting peptide can lead to formulations that supercharge the immune system’s ability to attack HPV-driven tumors.
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NewsStiff gels slow germs: New study maps hydrogel properties that control bacterial growth
Scientists has found that firmer, lower water content hydrogels limit bacterial growth, with implications for designing antibacterial coatings, infection models, and advanced medical materials.
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NewsGenotype-specific response to 144-week entecavir therapy for HBeAg-positive chronic hepatitis B
HBV genotype B demonstrates superior histological responses to ETV therapy compared with genotype C, supporting the clinical value of HBV genotyping for personalized CHB management. These findings highlight the importance of considering viral genotype when evaluating treatment outcomes.
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NewsResearchers identify strategies for preventing the most infectious strains of S. aureus in the NICU
A new study has identified which strains of Staphylococcus aureus – commonly known as staph – are commonly transmitted in neonatal intensive care units and which specific strains are most likely to cause invasive and serious infections.
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NewsNew algorithm enhances microbiome biomarker discovery by integrating biological relationships
Researchers have developed a novel algorithm, Microbiome Elastic Feature Extraction (MEFE), that significantly improves the identification of microbiome biomarkers by incorporating phylogenetic, taxonomic, and functional relationships among microbes.
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NewsResearchers develop simple at-home tests for detecting cat and dog viruses
Researchers report improved lateral flow assays for at-home screening of cats and dogs. In tests on veterinary clinic samples, the assays demonstrated 100% sensitivity and reproducibility for both feline parvovirus and canine parvovirus.