All Clinical & Diagnostics articles – Page 2
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NewsExpert consensus on clinical applications of fecal microbiota transplantation for chronic liver disease
To assist clinicians in rapidly mastering and standardizing the clinical application of FMT for chronic liver disease, an expert consensus has been developed to address key aspects of FMT application and provide reference and guidance for clinical practice.
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FeaturesFrom Petri dishes to chips: what can microbiology learn from microfluidics?
Microfluidics is a fast-growing field focused on manipulating tiny volumes of fluid, often within channels no wider than a human hair. Despite its potential, around 90% of microbial experiments are still carried out under static conditions. So, what are we missing by ignoring flow? And how can microfluidics help close the gap?
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NewsBreath carries clues to gut microbiome health
Researchers have shown that disease-associated bacteria in the gut can be detected through exhaled breath. They found that chemicals released by gut microbes and captured from the breath of children and mice can reveal the composition of the bacteria living in the intestines.
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NewsMajor clinical trial provides definitive evidence of impacts of steroid treatment on severe brain infection
A major UK clinical trial has shown that adding the corticosteroid dexamethasone to standard antiviral treatment for encephalitis, caused by herpes simplex virus (HSV) does not improve long-term outcomes overall, although early use may lead to better recovery.
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NewsValneva provides update on Chikungunya vaccine IXCHIQ®
Valneva SE has announced that the company has decided to voluntarily withdraw the biologics license application (BLA) and Investigational New Drug (IND) application for its chikungunya vaccine, IXCHIQ® , in the United States, following suspension of the license by the FDA.
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News58% of patients affected by 2022 mpox outbreak report lasting physical symptoms
A cohort study found that more than half of those diagnosed with mpox during the 2022 outbreak still had lingering physical effects 11 to 18 months later.
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NewsPregnant women hospitalized for COVID-19, and their newborns, have higher complication risk
When hospitalized for COVID-19, pregnant women — and their eventual newborn children — have a higher risk of complications. Research revealed that pregnant women were nearly 3.5 times more likely than non-pregnant women to require respiratory support when hospitalized for COVID-19.
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NewsA CRISPR fingerprint of pathogenic Candida auris fungi
Precision diagnostic platform integrating CRISPR and single molecule technology with AI enables rapid and accurate detection of drug-resistant Candida auris pathogens.
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NewsResearch reveals hidden diversity of E. coli driving diabetic foot infections
New research has shed light on the diversity and characteristics of E. coli strains that drive diabetic foot infections, providing the first comprehensive genomic characterisation of E. coli strains isolated directly from diabetic foot ulcers across multiple continents.
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NewsNew test could help pinpoint IBD diagnosis, study finds
A test that rapidly detects signs of inflammatory bowel disease (IBD) in stool samples could improve future diagnosis and monitoring of the condition, a study suggests. The luminescent reporter lights up when it detects a molecule linked to gut inflammation.
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NewsInjectable hydrogel-mediated co-delivery of oncolytic adenovirus and melphalan for retinoblastoma control and vision preservation
The collagen-based hydrogel enabled controlled oncolytic adenovirus and melphalan release and sustained retention. This approach eradicated retinoblastoma tumors and restored normal ocular structure and visual function following intravitreal administration.
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NewsSunlight-activated nanospray enables painless, antibiotic-free therapy for infected diabetic wounds
A research team has reported a multifunctional photodynamic nanospray for chronic infected wounds that harnesses natural sunlight to address persistent bacterial infections, impaired healing and severe pain simultaneously.
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NewsResearcher reveals secrets of bacteria that can swim upstream
Rather than washing pathogens away, strong fluid currents act as “guide rails” that align bacteria and accelerate their upstream migration. They discovered that this creates a “two-way invasion” where pioneer cells reach the source within minutes, seeding colonies that spread threefold faster than in still water.
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NewsNew biosensor technology could transform how viruses are detected
A new review highlights major advances in a promising class of diagnostic tools known as aptamer-based biosensors, which could help deliver faster, cheaper, and more portable virus testing in clinics, communities, and the field.
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NewsBeyond gene scissors: New CRISPR mechanism discovered
Two studies describe how researchers found a novel CRISPR mechanism, Cas12a2, in a family of nucleases that exclusively cleave DNA. In contrast, Cas12a2 was able to broadly cleave both RNA and DNA.
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NewsCRISPR discovery could lead to single diagnostic test for COVID, flu, RSV
Researchers report newly discovered details about the Cas12a3 immune system that precisely targets transfer RNA in invading pathogens, without destroying host cells.
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NewsNew clinical standards strengthen antimicrobial stewardship in tuberculosis care
An international panel of experts from 32 countries has presented specific antimicrobial stewardship standards for TB care for the first time.
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NewsHigh-dose antibiotic does not reduce mortality in tuberculous meningitis
The first trial examining the effects of higher rifampicin doses on tuberculosis survival has been completed. The study found no evidence of a beneficial effect from high-dose rifampicin.
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NewsFiltering the invisible: New evidence points to more efficient indoor air microbe sampling
Using fluorescence-based detection, a new study provides clear, quantitative evidence that sampling principle, collection medium, and airflow rate strongly shape how well indoor microbial aerosols can be measured.
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NewsScientists identify potential therapy and diagnostic markers for cerebral malaria
Researchers examined whether methylene blue could mitigate brain injury during severe malaria, and whether a practical set of blood biomarkers could help clinicians identify cerebral malaria early and track how patients respond to treatment.