All Clinical & Diagnostics articles
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Human Organ Chip technology sets stage for pan-influenza A CRISPR RNA therapies
Human lung alveolus chip infection model enables investigation of viral replication, inflammatory responses, and genetic off-target effects of a novel pan-influenza CRISPR therapy.
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Gut microbiota disruption predicts severe steatosis in MASLD patients
A new study links gut dysbiosis with severe steatosis in metabolic dysfunction–associated steatotic liver disease (MASLD). In a 61-patient cohort, those with the inflammation-linked Bact2 enterotype developed severe steatosis at lower thresholds.
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Researchers developing new easy-to-use viral biosensor test, giving patients more accurate and immediate results
An interdisciplinary team of researchers is creating a single low-cost test to detect HIV & Hepatitis B and C simultaneously, that may be used in resource-limited settings. With quicker and more accessible results, the test has potential to save lives.
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Two-dose recombinant shingles vaccine is effective even accounting for prior receipt of live shingles vaccine
A target trial emulation was conducted to assess the effectiveness of recombinant zoster vaccine (RZV) accounting for prior receipt of live zoster vaccine (ZVL) and immunocompetence. The results suggest individuals vaccinated with ZVL should be revaccinated with two doses of RZV.
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Pioneering gut health testing with a simple finger prick
Zinzino, the Scandinavian health and wellness company, has announced the launch of its innovative Gut Health Test. With a simple at-home finger prick, this is the first commercial test to measure what gut bacteria produce and how the body responds.
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Heart rhythm disorder POTS common in patients with long COVID
A new study shows that an unusual heart rhythm disorder, POTS, is particularly common in people with long COVID. The majority of those affected are middle-aged women.
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Potential biomarker for the development of long COVID identified
A research team has demonstrated that a specific component of the immune system (PTX-3) remains at significantly higher levels in the blood of patients who have suffered from severe COVID-19, even months after the acute infection has subsided.
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A step toward diagnosing the flu with your tongue
A new molecular sensor has been designed to release a thyme flavor when it encounters the influenza virus. Researchers plan to incorporate this type of low-tech sensor into gum or lozenges to increase at-home screenings and potentially prevent pre-symptomatic transmission of the disease.
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Brain imaging technique helps uncover the molecular basis of long COVID brain fog
A research team has made a significant breakthrough in understanding the cause of Long COVID brain fog. They hypothesized that patients with brain fog might exhibit disrupted expression of AMPA receptors (AMPARs)based on prior research into psychiatric and neurological disorders.
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Emerging serum biomarkers for chronic hepatitis B: Focus on serum HBV RNA and HBcrAg
There is a pressing need for non-invasive biomarkers that can accurately reflect the activity of the hepatitis B viral reservoir and predict clinical outcomes. This review synthesizes the evidence for two such promising biomarkers: serum HBV RNA and hepatitis B core-related antigen (HBcrAg).
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‘Alarming’ rise in newborn babies with antibiotic-resistant infections, researchers find
Researchers are calling for an urgent overhaul of diagnostic and treatment guidelines for infections in newborn babies, after a study revealed frontline treatments for sepsis are no longer effective to treat the majority of bacterial infections.
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New one-hour, low-cost HPV test could transform cervical cancer screening in Africa and beyond
A team of researchers has developed a simple, affordable human papillomavirus (HPV) test that delivers results in less than an hour with no specialized laboratory required.
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Global Virus Network launches multi-country mpox diagnostic evaluation to close global preparedness gaps
The Global Virus Network has initiated one of the first coordinated, multi-country evaluations of rapid point-of-care mpox diagnostics, a critical step to prevent resurgence and ensure the world is better prepared for future epidemics.
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Beyond viruses: Expanding the fight against infectious diseases
The newly renamed Gladstone Infectious Disease Institute has broadened its mission to address global health threats ranging from antibiotic resistance to infections that cause chronic diseases.
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RSV vaccines safe and effective, Cochrane review finds
A new Cochrane review demonstrates that vaccines for respiratory syncytial virus (RSV) are both safe and effective in protecting vulnerable groups that are most at risk of serious illness, including older adults and infants.
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Review shows around one in three hospital infections involve antimicrobial resistance
With an estimated 1.14 million deaths worldwide annually caused by bacteria becoming resistant to antibiotics, a study shows that in hospital settings antimicrobial resistance is common and independently associated with a higher risk of death.
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New study finds dried blood spot test reliably detects congenital CMV at birth
New research confirms that testing for congenital cytomegalovirus (cCMV) at birth using the routinely collected dried blood spot (DBS) is a reliable and effective method to identify newborns at risk for long-term developmental challenges.
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Scientists develop a virus cocktail to combat superbugs
Researchers have developed a bespoke phage therapy, Entelli-02, a five-phage cocktail designed specifically to target Enterobacter cloacae complex (ECC), a group of bacteria responsible for severe, often difficult-to-treat infections.
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Yeast in gut microbiome can worsen salmonella infection
Researchers have discovered that a yeast commonly found in our gut can make infection with salmonella worse. Salmonella binds to Candida albicans and triggers a chain reaction that allows the bacteria to better invade cells lining the intestines.