All Vaccinology articles
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Pediatric investigation review discusses the challenges, innovations, and future directions in dengue vaccine development
A new review discusses the current status and implications of dengue vaccines like CYD-TDV, TAK-003, and Butantan-DV while exploring the challenges in Dengue vaccine development like ADE, and proposes future directions in this field.
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COVID-19 vaccinations are metabolically safe, research finds
New research confirms that multiple doses of COVID-19 vaccines do not cause significant metabolic changes, offering reassurance for those concerned about potential long-term side effects of vaccination.
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Measles may be making a comeback in the US, research finds
If immunization rates drop further over a prolonged period of time, measles and even other wiped-out diseases — such as rubella and polio — could one day make a comeback in the United States, according to a new study.
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Every dose counts: Safeguarding the success of vaccination in Europe
Marking European Immunization Week (EIW) 2025, a new report highlights the risks of suboptimal vaccination coverage in Europe and publishes a set of operational tools that public health authorities can use to improve vaccination acceptance and uptake.
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European Immunization Week 2025: Inequalities in immunisation against measles could contribute to outbreaks
Research reveals inequalities in MMR vaccination that may contribute to measles outbreaks and epidemics, emphasising the importance of socioeconomic and demographic data in driving public health efforts.
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BNT162b2 vaccine not only targets COVID-19 virus, but may also help control innate inflammation
New findings suggest the BNT162b2 vaccine may reduce the production of pro-inflammatory mediators to bacterial, fungal or viral infections by reprogramming innate immune cells to regulate inflammation.
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Study: Experimental bird flu vaccine excels in animal models
A vaccine has demonstrated complete protection in mice against a deadly variant of the virus that causes bird flu. It focuses on the H5N1 variant known as 2.3.4.4b, which has caused widespread outbreaks in wild birds and poultry.
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Dr. Sabine Ehrt named Chair of the Department of Microbiology and Immunology at Weill Cornell Medicine
Dr. Sabine Ehrt, an internationally renowned leader in tuberculosis research, has been appointed chair of the Department of Microbiology and Immunology at Weill Cornell Medicine.
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Experts stress importance of vaccination amidst measles outbreaks
Pediatric infectious diseases experts stress the importance of vaccination against measles, one of the most contagious viruses, which is once more spreading in the United States.
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Investing in COVID-19 vaccination more than paid off for U.S., study finds
The US national Covid-19 vaccine strategy more than paid for itself after just one year, according to a new study. Because the vaccines reduced how many people developed serious illness or died, the nation saved more money than it spent.
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COVID-19 vaccination induces long-lasting antibody B-cell responses
A research study revealed that memory B cells maintain long-lasting and stable responses prior to mRNA vaccinations for COVID-19, but updated vaccines targeting new variants could boost immunity.
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Viral ‘backbone’ underlies variation in rotavirus vaccine effectiveness
A new study has shown that full-genome differences between rotavirus strains influence vaccine effectiveness, highlighting the need for a broader approach to vaccine design.
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Scientists develop nasal spray H5N1 avian influenza vaccine
Scientists have pioneered an influenza virus vector-based nasal spray vaccine platform and developed a nasal spray H5N1 avian influenza vaccine.
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New research boosts future whooping cough vaccines
By blocking the pertussis toxin epitopes with new found antibodies, researchers improved the pertussis vaccines to provide stronger, long-lasting immunity for infected and high-risk infants.
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Alternative approach to Lyme disease vaccine development shows promise in pre-clinical models
An international research team finds genetically engineered Lyme bacterial proteins could offer long-standing protection against infection while requiring fewer vaccinations.
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The beginning of the end: Setting a global target for rubella eradication
Scientists discuss the 2024 World Health Organization’s (WHO) recommendation for universal introduction of rubella-containing vaccines (RCVs) into childhood vaccination programs in all countries – particularly in the remaining 19 countries that have yet to do so.
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MOPEVACLAS vaccine candidate for Lassa fever enters clinical trials
After more than 20 years of research on arenaviruses, researchers have developed an original vaccine platform known as MOPEVAC. A Phase Ia clinical trial is set to begin for the platform’s first vaccine candidate, which targets Lassa fever, a hemorrhagic fever responsible for thousands of deaths worldwide each year.
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mRNA-based COVID-19 vaccines train the ‘long-term memory’ of the innate immune system
A study showed that vaccination of multiple mRNA-based COVID-19 vaccines could induce persistent epigenetic changes in innate immune cells, leading to long-term immune responses for SARS-CoV-2 and other pathogens.
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‘It’s a shot, not a vaccine like MMR’: New skepticism prompts call for action
This ‘vaccine is not a vaccine’ is a new, previously unreported type of vaccine-specific scepticism, and it arose only during the COVID-19 pandemic. However, it might, according to the researchers, also apply to the flu vaccine.
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How Zika virus knocks out our immune defenses
Scientists have made striking discoveries regarding the different infection mechanisms of Zika and dengue virus of the same viral family. These understandings pave the way for vaccine development to combat flaviviruses with similarities.