All Phage Therapy articles
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FeaturesBuilding integrated biobanks to defeat AMR in chronic wounds
Antimicrobial resistance (AMR) has evolved into a complex global health issue which has outstripped the development of new antibiotics and therapeutic strategies. The World Health Organisation (WHO) estimates 1.27 million deaths were attributed to AMR infections in 2019. By 2050, 10 million deaths are predicted at a cost of $100 ...
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NewsVIRE: a global data platform to better understand viruses
Researchers have released a comprehensive viral genome database covering diverse ecosystems to advance the understanding of viral evolution and ecosystem functions.
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NewsHow reactive oxygen species target viruses differently: new clues for safer water disinfection
A new study systematically explored how reactive oxygen species (ROS) inactivate viruses with distinct structures. The results revealed clear heterogeneity: enveloped RNA viruses were most susceptible to oxidation, while double-stranded DNA viruses showed strong resistance.
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NewsMucosal virome and host transcriptome interactions reveal viral influence in colorectal polyp development
A new study has provided the first integrated mucosal virome-transcriptome landscape of colorectal polyps, the precursors of colorectal cancer, offering new insights into viral-host interactions at this early disease stage.
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NewsUnder The Lens: Callum Cooper explores how bacteriophages could revolutionise medicine - and how we get to that point
In a compelling new video interview from Applied Microbiology International’s ‘Under the Lens’ series, Dr. Callum Cooper shares fascinating insights into one of medicine’s most promising frontiers: phage therapy.
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VideoThe Microbiologist: Under the Lens | Episode 2
In our second episode, Dr Callum Cooper joins Professor Emmanuel Adukwu to talk about all things bacteriophage, from alternatives to antibiotics, social impact, and regulation.
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NewsDr José Luis Balcazar named as winner of John Snow Public Health Innovation Prize
Dr José Luis Balcazar, Senior researcher at the Catalan Institute for Water Research (ICRA-CERCA), Spain, has been named as the newest winner of the John Snow Public Health Innovation Prize.
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NewsFive new phages discovered in university’s Botanical Gardens
Five new bacteriophages have recently been discovered in the ponds of Lund University’s Botanical Gardens. Phages thrive wherever bacteria are found, which often means ponds and watercourses that are rich in organic material.
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NewsNew collection of bacteria-eating viruses can tackle hospital superbug
An international team of researchers have comprehensively catalogued a new collection of bacteria-eating viruses called phages sourced, in part, from hospital wastewater. The phages have been shown to be effective against different strains of Klebsiella pneumoniae.
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NewsTeam discovers cyanobacteria activate different genes by day and by night
By analyzing gene expression in the cyanobacterium Nostoc punctiforme, scientists discovered that during daylight, the cells focus on metabolism. But under cover of darkness, they turn to the control of genome repair and activate various genetic elements.
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NewsResearchers expand virus-based treatment options for antibiotic-resistant infections
Phages are extremely specific about which strains of a bacterial species they will attack. This has limited their effectiveness against the most antibiotic-resistant strains. To overcome this problem, the research team “trained” the phages by allowing them to evolve together with the bacteria in a controlled laboratory setting for 30 days.
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OpinionThe politics behind the global divide in bacteriophage therapy
The therapeutic potential of bacteriophages (or ‘phages’) has been widely dismissed for decades in the West, despite being regularly used to treat patients worldwide in the early and mid-20th century. In an age rife with disinformation, can the true potential of clinical phage technology be communicated to a public already uneasy about scientific intervention?
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NewsBacteriophage characterization provides platform for rational design
Researchers have described the bacteriophage Bas63 in unprecedented detail, supporting new mechanistic understanding of how these viruses function.
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NewsPhages with fully-synthetic DNA can be edited gene by gene
Scientists have developed a method to construct bacteriophages with entirely synthetic genetic material, allowing researchers to add and subtract genes at will.
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NewsGut microbiota: implications in pathogenesis and potential therapeutic target in primary biliary cholangitis
A new review synthesizes current evidence on gut microbiota dysbiosis in PBC, elucidates its pathogenic mechanisms, and explores its potential as both a diagnostic biomarker and a novel therapeutic target.
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NewsResearchers discover novel phage DNA modifications that offer new hope against antibiotic-resistant superbugs
A groundbreaking discovery reveals a unique way phages modify their DNA with arabinose sugars to protect themselves from bacterial defence systems. Natural DNA phage modifications occur at a higher rate than previously predicted, the study revealed.
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NewsDiscovery of hundreds of new human gut viruses provides a new approach to studying the gut microbiome
Hundreds of new viruses living inside bacteria within our gut have been discovered in an international study. These bacteriophages could eventually be used to reshape the gut microbiome, potentially influencing gut health and the progression of various disease states.
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NewsResearchers partner on $28M initiative to build a precision phage platform for promoting public health
Researchers have embarked on a five-year initiative that aims to harness the natural predators of bacteria – known as phages – as precision tools to shape the human microbiome and promote health.
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NewsSpotlight on phage for a fascinating policy discussion
Scientists turned the spotlight onto the potential of phage in a recent AMI webinar that yielded a fascinating in-depth discussion that proved invaluable in clarifying the way forward. The ‘Phages for a Sustainable Future’ webinar has now been released as a video.
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NewsBeyond viruses: Expanding the fight against infectious diseases
The newly renamed Gladstone Infectious Disease Institute has broadened its mission to address global health threats ranging from antibiotic resistance to infections that cause chronic diseases.