All Phage Therapy articles
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NewsPIXL Max: Automated colony picker breaks records for speed and accuracy
With the latest innovation from the team at Singer Instruments, a new standard for speed and repeatability in microbial colony pickers has been achieved through the integration of cutting edge AI technologies.
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NewsNexaBiome accelerates development of novel diabetic foot treatment with Scottish Enterprise funding
UK biotechnology company NexaBiome Life Sciences Ltd has received continued funding from Scotland’s national economic development agency, Scottish Enterprise, to accelerate its breakthrough bacteriophage technology for the treatment of diabetic foot infections (DFIs).
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NewsGolden Gate method enables rapid, fully-synthetic engineering of therapeutically relevant bacteriophages
Researchers have described the first fully synthetic bacteriophage engineering system for Pseudomonas aeruginosa. In this method, researchers engineer bacteriophages synthetically using sequence data rather than bacteriophage isolates.
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FeaturesUnlocking the secrets of phages: DNA modification discoveries offer new weapons against antimicrobial resistance
Bacteria and their viral predator bacteriophages (phages) have coevolved for billions of years and are engaged in an endless arms race against each other. DNA modifications are among the most widespread defenses to block bacterial RM and CRISPR-Cas systems.
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NewsAboard the International Space Station, viruses and bacteria show atypical interplay
In a new study, terrestrial bacteria-infecting viruses were still able to infect their E. coli hosts in near-weightless “microgravity” conditions aboard the International Space Station, but the dynamics of virus-bacteria interactions differed from those observed on Earth.
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NewsScientists reveal how excess hydrogen triggers metabolic shifts and viral defense in syngas microbiomes
Syngas biomethanation—converting CO/CO₂/H₂ into renewable methane—relies on coordinated microbial interactions. A study reveals that excess hydrogen disrupts this balance, reducing methanogenesis efficiency and triggering major shifts in microbial metabolism and viral dynamics.
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News4 million euros for study with personalized phage therapy
UMC Utrecht has received a grant of 4 million euros for the first clinical study in the Netherlands involving a customized therapy with bacteriophages for patients with recurrent urinary tract infections.
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FeaturesBuilding integrated biobanks to defeat AMR in chronic wounds
Antimicrobial resistance (AMR) has evolved into a complex global health issue which has outstripped the development of new antibiotics and therapeutic strategies. The World Health Organisation (WHO) estimates 1.27 million deaths were attributed to AMR infections in 2019. By 2050, 10 million deaths are predicted at a cost of $100 ...
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NewsSingle-cell movies reveal how host physiology sets phage success - and how to time therapies
A new study outlines how an innovative imaging platform can be used to help uncover the reasons why phages succeed or fail when used to target bacterial infections.
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NewsVIRE: a global data platform to better understand viruses
Researchers have released a comprehensive viral genome database covering diverse ecosystems to advance the understanding of viral evolution and ecosystem functions.
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NewsHow reactive oxygen species target viruses differently: new clues for safer water disinfection
A new study systematically explored how reactive oxygen species (ROS) inactivate viruses with distinct structures. The results revealed clear heterogeneity: enveloped RNA viruses were most susceptible to oxidation, while double-stranded DNA viruses showed strong resistance.
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NewsMucosal virome and host transcriptome interactions reveal viral influence in colorectal polyp development
A new study has provided the first integrated mucosal virome-transcriptome landscape of colorectal polyps, the precursors of colorectal cancer, offering new insights into viral-host interactions at this early disease stage.
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NewsUnder The Lens: Callum Cooper explores how bacteriophages could revolutionise medicine - and how we get to that point
In a compelling new video interview from Applied Microbiology International’s ‘Under the Lens’ series, Dr. Callum Cooper shares fascinating insights into one of medicine’s most promising frontiers: phage therapy.
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VideoThe Microbiologist: Under the Lens | Episode 2
In our second episode, Dr Callum Cooper joins Professor Emmanuel Adukwu to talk about all things bacteriophage, from alternatives to antibiotics, social impact, and regulation.
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NewsDr José Luis Balcazar named as winner of John Snow Public Health Innovation Prize
Dr José Luis Balcazar, Senior researcher at the Catalan Institute for Water Research (ICRA-CERCA), Spain, has been named as the newest winner of the John Snow Public Health Innovation Prize.
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NewsFive new phages discovered in university’s Botanical Gardens
Five new bacteriophages have recently been discovered in the ponds of Lund University’s Botanical Gardens. Phages thrive wherever bacteria are found, which often means ponds and watercourses that are rich in organic material.
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NewsNew collection of bacteria-eating viruses can tackle hospital superbug
An international team of researchers have comprehensively catalogued a new collection of bacteria-eating viruses called phages sourced, in part, from hospital wastewater. The phages have been shown to be effective against different strains of Klebsiella pneumoniae.
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NewsTeam discovers cyanobacteria activate different genes by day and by night
By analyzing gene expression in the cyanobacterium Nostoc punctiforme, scientists discovered that during daylight, the cells focus on metabolism. But under cover of darkness, they turn to the control of genome repair and activate various genetic elements.
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NewsResearchers expand virus-based treatment options for antibiotic-resistant infections
Phages are extremely specific about which strains of a bacterial species they will attack. This has limited their effectiveness against the most antibiotic-resistant strains. To overcome this problem, the research team “trained” the phages by allowing them to evolve together with the bacteria in a controlled laboratory setting for 30 days.
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OpinionThe politics behind the global divide in bacteriophage therapy
The therapeutic potential of bacteriophages (or ‘phages’) has been widely dismissed for decades in the West, despite being regularly used to treat patients worldwide in the early and mid-20th century. In an age rife with disinformation, can the true potential of clinical phage technology be communicated to a public already uneasy about scientific intervention?